De Novo Lipogenesis (DNL) literally means “Making Fat”. PPAR gamma is the master regulator of fat making. It regulates the lipogenic genes include SCD1, FAS and ELOVL. A key regulatory step in DNL is the carboxylation of Acetyl-CoA into malonyl-CoA. This is the first, rate limiting step in DNL and is done by the enzyme Acetyl-CoA Carboxylase (ACC). ACC is turned off by being phosphorylated by AMPK and turned on by desphosphorylation by Protein Phosphatase 2(PP2A).
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Synonyms:
DNL, De Novo Lipogenesis, FAS, ELOVL, ACC, elongase, desaturase, Acetyl-coa carboxylase, malonyl-coa, PP2A, protein phosphatase 2