Reactive Oxygen Species

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Reactive oxygen species (ROS) are pro-oxidants. They are produced in many places, but this blog is largely focuses on mitochondrial ROS produced during respiration. ROS is generated as superoxide, which is rapidly converted to hydrogen peroxide. Hydrogen peroxide does it job by switching on or off redox-sensitive enzymes. ROS are a signal from the mitochondria that tells the rest of the cell what is happening from a fuel burning perspective. Burning long chain saturated fat quickly generates the most ROS due to the high FADH2/NADH ratio which overloads the mitochondrial bottleneck. Burning unsaturated fats and/or glucose generate minimal ROS.

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ROS, superoxide, hydrogen peroxide
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