Fat Metabolism in Context: PPAR alpha, Saturated Fat and NAD+

PPAR alpha is a nuclear receptor that is often said to be crucial for fat metabolism.  It increases the activity of enzymes that increase fat flow into mitochondria and increase beta oxidation: fat burning.

Having said that, the functions of PPAR alpha are largely redundant with PPAR delta, which is more highly expressed in most tissues.  PPAR alpha also has some “odd” activities, such as increasing lipogenic enzymes such as SCD1 and D6D.  This leads to making fat while burning fat.  A curious effect.

PPAR alpha is activated by the oleic acid in olive oil and the lauric acid in cocnut oil.  In this video I argue that the CONTEXT within which you activate PPAR alpha is of crucial importance.  Saturated fat leads to high NAD+ levels leads to PPAR alpha activating fat burning. Unsaturated fat leads to low NAD+ levels leads to PPAR activating fat making.

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