I gave a lecture on The ROS Theory Of Obesity at Interbrook Farm in Sept of 2019. I made hand drawn slides with a Sharpie. Unfortunately my sense of humor is on full display in these. Maybe they’ll be useful to someone. Also, u/leerylizard posted an annotated guide to the ROS Theory Of Obesity on …
The Illustrated Guide And Annotated Guide to The ROS Theory of Obesity Read More »
After publication of The Croissant Diet, which promotes a diet combining highly saturated fat and starch for weight loss, I got a lot of questions along the lines of whether it mattered if fat was eaten before starch. Or maybe protein should be consumed first? The proposed mechanism of the croissant diet is that saturated …
Fat From The Previous Meal Sets The Metabolic Table Read More »
At the beginning of this series I stated that any theory of obesity should be able to explain why a Chinese peasant eating a very low fat diet with the bulk of calories furnished by white rice – a refined carbohydrate – is lean, a French person eating a mixed fuel diet of starch, sugar, …
Satiation is a feeling that is actually triggered in the brain by specific neurons in the hypothalamus. These neurons respond to a number of factors, including circulating levels of blood glucose, free fatty acids (ie energy availability) and hormones such as leptin. In this paper, the authors show that ROS is necessary for satiation. The …
This paper measured the level of Stearoyl-CoA desaturase in morbidly obese adults compared to adults with a normal BMI. The obese adults produce 2-3 times as much of the enzyme as do lean adults, resulting in fat that is significantly more unsaturated. In addition, the obese adults also had much higher levels of polyunsaturated fats. …
The Body Fat of Obese Adults is Highly Unsaturated Read More »
A “knockout mouse” is a strain of mice in which a section of their DNA has been deleted. Therefore, they do not have a particular gene. Sometimes, this has disastrous consequences, certain genes they cannot live without and thus they are never born. But when a knockout mouse lives, it can teach us interesting lessons …
When fat cells respond to insulin they take several actions in switching from fat burning mode to glucose burning and fat storing mode. These actions include: Turning off lipolysis – the process of releasing fats into the bloodstream as Free Fatty Acids which other cells can use energy Absorbing Glucose and beginning de no lipogenesis …
Butter Causes a High Level of Available Energy 8 Hours After a Meal Read More »
If you’ve been reading along you know that by this point we’ve shown that long chain saturated fat consumption causes ROS production in the mitochondria which causes short term physiological insulin resistance. The ROS theory of obesity suggests that physiological insulin resistance should prevent fat storage in peripheral fat cells (adipocytes). I’ve been dancing around …
Long Chain Saturated Fat Causes Fat Loss in Mice Read More »
In this series we’ve discussed the fact that saturated fat oxidation leads to ROS production in the mitochondria which makes peripheral fat cells “physiologically insulin resistant” which prevents them from switching from fat burning to fat storage. We’ve shown that saturated fat reversibly induces insulin resistance in people in the short term and that a …
This paper studied the effect of a ketogenic diet composed largely of saturated fat compared to one composed largely of unsaturated fat. Ketogenic diets are high in fat and low in carbohydrate and protein. Ketogenic diets are known to stimulate physiological insulin resistance that goes away after a few days of eating a carbohydrate rich …
Unsaturated Fat Prevents Physiological Insulin Resistance In Humans Read More »
In previous posts I have laid out the argument that metabolism of long chain saturated fat creates mitochondrial ROS which causes short term insulin resistance while the saturated fat is oxidized. Insulin tells the bodies cells to switch from fat metabolism to glucose metabolism and causes fat cells to absorb glucose, convert it to fat …
Saturated Fat Causes Physiological Insulin Resistance in Humans Read More »
In this series I often mention that mitochondrial ROS production creates physiological insulin resistance which keeps your cells in “fat burning mode”. In this paper, the authors actually took a picture of fat burning mode!! They asked human subjects to eat a low fat vegan diet for two days and then gave them a banana …
Let’s think about what happens in response to a starchy meal. Blood sugar rises and insulin is released. Insulin attaches to the insulin receptors on the cell membranes of muscle cells, fat cells, etc. The cells respond by moving a glucose transporter, GLUT4, into the cell membrane so that they can start importing glucose. Insulin …
In the introductory series, we first saw an example of ROS (Reactive Oxygen Species) as a signal in a small worm (nematode) called c. elegans. When glucose oxidation in c. elegans is blocked, the worms shift to burning fat which creates more ROS which ultimately leads to a longer lifespan for the worm. Why does …
A mitochondria works like a battery. It maintains a voltage gradient across its inner-membrane. The outside of the membrane has a positive charge and the inside has a negative charge. Protons from the outside flow back through the membrane down the gradient, releasing energy, through a large cross-membrane protein complex called ATP synthase, which uses …
