Searchable, Sortable Blog Index

DateTitleSummaryCategories
July 7, 2021Brad on Peak Human podcast

Brad talking about the latest Fire In A Bottle concepts with Brian Sanders. We pack …

Podcasts
July 7, 2021Brad on The Mr. Bill podcast

Mr Bill’s podcast is not a health-based, typically. This is a great starting point if …

Podcasts
July 7, 2021Brad on The Natural State with Dr Anthony Gustin

This 2 part podcast is comprehensive look at the topics discussed on Fire In A …

Podcasts
July 7, 2021Brad Talks Torpor with David Gornoski

This is wide-ranging discussion about the ideas discussed on Fire In A Bottle, including torpor, …

Podcasts
June 26, 2021Accumulating Linoleic Acid Prevents Diabetes

This is from the EPIC Potsdam study in Germany, which looked at the association between …

Torpor, Sloth and Gluttony
June 23, 2021Obesity prone pigs go from Normal to Pathological Insulin Sensitivity to Torpor when given enough PUFA

Hap MD asked me if I had any thoughts on Ossabaw pigs.  They are interesting …

Torpor, Sloth and Gluttony
June 16, 2021This Is How Linoleic Acid Makes You Fat, Leptin Resistant and Torpid

I’ve written a lot about the strong correlation between the Desaturase Index (DI) and human …

Torpor, Sloth and Gluttony
June 14, 2021Bio-Hacking Leptin

I mentioned somewhere that I was leptin resistant somewhere and in the comments of the …

Torpor, Sloth and Gluttony
June 10, 2021The Cruel Irony of “Eat Less, Move More”

There are many believers in a reductionist calories in, calories out (CICO) view of the …

Torpor, Sloth and Gluttony
June 9, 2021Leptin Increase Your Metabolic Rate And Keeps You Lean By Making You Inefficient at Walking

Introduction This is part of my Torpor, Sloth and Gluttony series where I will argue …

Torpor, Sloth and Gluttony
June 4, 2021Sterculia Oil Prevents Liver Fat Accumulation and Prevents Insulin Resistance in Fructose-Fed Rats

In the comments of SCD1 CAUSES Humans to Store Fat, David N posted a link …

The SCD1 Theory Of Obesity
June 3, 2021David Tillman Shares His Amazing Croissant Diet Story

David has been featured on the blog before under the testimonial David’s Story. He’s lost …

The Croissant Diet
May 22, 2021Torpor, Sloth and Gluttony: SCD1 CAUSES Humans to Store Fat

Introduction My thesis in this series is that humans get fat NOT from sloth and …

Torpor, Sloth and Gluttony
May 22, 2021Torpor, Sloth and Gluttony Part 1: Americans ate a LOT in 1939

Introuction to Torpor, Sloth an Gluttony This is the first post in my new “Sloth …

Torpor, Sloth and Gluttony
April 28, 2021Female Amazonian forager-horticulturalists have the same metabolic rate as Korean college students. They both eat mostly starch. Their body fat is Saturated.

The title of “High resting metabolic rate among Amazonian forager-horticulturalists experiencing high pathogen burden” makes …

The SCD1 Theory Of Obesity
April 15, 2021Humans and Hibernating Mammals React to The Same Amount of Dietary Linoleic Acid in the Same Way. By Becoming Torpid.

As a biologist, I always think in evolutionary terms. All mammals share a single ancestor …

The SCD1 Theory Of Obesity, Torpor, Sloth and Gluttony
April 14, 2021n=1 on Escaping Torpor: Turning off PPAR gamma and turning on Fat Burning

Recently I posted an article recommending combining sterculia oil with berberine and/or fish oil as …

The SCD1 Theory Of Obesity
April 9, 2021Metabolic Rates In American Men Plunged Between 1919 and 1987

Introduction If you follow this blog you probably won’t be SHOCKED that I’m following up …

Torpor, Sloth and Gluttony
March 29, 2021Metabolic Rates in American Women Plunged Between 1919 and 1986

Intro I have suggested that increased consumption of the Omega 6 polyunsatured fat (PUFA) linoleic …

Torpor, Sloth and Gluttony
March 20, 2021Sterculia Oil: How to Escape Torpor!

Brad’s Daily Recipe Introduction I’d like to reach my target weight this year or next, …

Sterculia Oil, The SCD1 Theory Of Obesity
March 20, 2021Sterculia Oil: Metabolic Results Number One

Inroduction So I have a fancy metabolic tester to track my metabolic rate. It’s honestly …

Sterculia Oil, The SCD1 Theory Of Obesity
March 20, 2021Sterculia Oil: Brad’s Blood Numbers and Safety

Study Design I started my sterculia oil (SO) trial with a 16 week n=1 safety …

Sterculia Oil, The SCD1 Theory Of Obesity
March 9, 2021Are You In Deep Torpor? SCD1 Theory Of Obesity Summary So Far And Hamsters!

Introduction It’s time for the season finale! Next week I will pivot to discussing my …

The SCD1 Theory Of Obesity
March 6, 2021Very Long Chain Saturated and Monounsaturated Fats

Overview Very Long Chain Fatty Acids (VLCFA) I’ve become very interested in very long chain …

The SCD1 Theory Of Obesity
March 4, 2021Membrane Phospholipid Composition of Different Populations

I’ve been promoting the OmagaQuant complete test as a way to calculate your Desaturase Indix …

The SCD1 Theory Of Obesity
March 3, 2021Good PPAR, Bad PPAR

Overview Introduction I introduced PPAR alpha in Dietary Monounsaturated Fat as an altogether good actor, …

The SCD1 Theory Of Obesity
March 1, 2021Fat Newborns; Sloth and Gluttony Part 1

Introduction The most common explanation given for the recent wave of obesity is that “We …

The SCD1 Theory Of Obesity
February 26, 2021David’s Story

This is a pretty great testimonial to the potential of The Croissant Diet. David really …

Testimonials
February 22, 2021Really Good Historical Video About The History of SCD1 research Posted at r/SaturatedFat

This was posted by a user of the reddit group r/SaturatedFat. This is a great …

Podcasts
February 21, 2021Bear Hunting Season; Native Americans Hunted Bear When The PUFA Content Was Lowest

Introduction This is a followup to my post Native Americans Removed Acorn Oil and Replaced …

The SCD1 Theory Of Obesity
February 17, 2021Lori’s Story

Lori reached out to me wanting to share her story. She initially sent me this …

Testimonials
February 15, 2021The Body Fat Saturation Of Starch Eaters; Linoleic Acid Dysregulates SCD1

I’ve argued in The SCD1 Theory of Obesity Part One and Part Two, as well …

The SCD1 Theory Of Obesity
February 4, 2021Native Americans Removed Acorn Oil and Replaced It With Bear Fat

Introduction In a previous article, I argued that a recent drop in the body temperatures …

The Croissant Diet, The SCD1 Theory Of Obesity
February 2, 2021Low Carb MD

They really let anyone on podcasts these days! Listen to Brad join obesity clinic doctors …

Podcasts
February 2, 2021Speed Your Metabolism With Oxidative Stress! Slow It With Antioxidants!

It’s rare to find a scientific paper whose RESULTS are hilarious. Sometimes the authors conclusions …

Intro To Oxidation, The Croissant Diet, The ROS Theory of Obesity, The SCD1 Theory Of Obesity
January 30, 2021This is Your Body Temperature on Vegetable Oil

Introduction This article suggests that the reason the Tsimane people of Bolivia experienced a significant, …

The Croissant Diet, The SCD1 Theory Of Obesity
December 15, 2020Brad Talking SCD1 Theory of Obesity with Raphael Sirtoli

World premiere SCD1

Podcasts, The SCD1 Theory Of Obesity
December 15, 2020New List of Additional SCD1 Regulators posted at r/SaturatedFat

There is a great discussion thread for Croissant Diet/ROS Theory of Obesity/SCD1 Theory of Obesity …

The SCD1 Theory Of Obesity
December 9, 2020Pu’erh Tea is a potent Suppressor of SCD1

Katie sent me this paper.​1​ It actually adds an interesting twist to her story that …

The Croissant Diet, The SCD1 Theory Of Obesity
December 3, 2020Dietary Monounsaturated Fat, The SCD1 Theory of Obesity, Part 3

Introduction This is the third part of my SCD1 Theory of Obesity series.  Here are …

The SCD1 Theory Of Obesity
November 16, 2020The SCD1 Theory of Obesity Part 2 – The Post Obese Metabolism and What You Can Do About It

AKA The Ros Theory of Obesity Part2, Part 2 Introduction In part 1, I explained …

The SCD1 Theory Of Obesity
November 16, 2020The SCD1 Theory of Obesity, Part 1 – Insulin, Leptin, SCD1 and Thermogenesis

AKA The ROS Theory of Obesity Part 2, Part 1 Introduction In The ROS Theory …

The SCD1 Theory Of Obesity
October 24, 2020Brad on Ben Greenfield!

The podcast is out! Excellent chat with Ben. Check it …

Podcasts
October 24, 2020Brad’s Inflammation Blood Test Numbers – Don’t Conflate Inflammation and ROS!

So I do everything wrong, kind of on purpose. I eat white flour and dairy. …

The Croissant Diet
October 21, 2020Kirsten’s TCD Post

Kirsten Mortenson, a novelist, posted a nice writeup of her experience with TCD after almost …

Testimonials
October 20, 2020Podcasts!

I’ve had a busy summer of recording podcasts! There are hours of me blathering on …

Podcasts
October 20, 2020Katie’s Story

Katie is doing a textbook version of TCD. I love her story, it’s honest and …

Testimonials
October 19, 2020James’ Story

James posted his success with TCD on Reddit. I reached out to see if he …

Testimonials
September 15, 2020Butter May Lower LPS Mediated Inflammation Compared to Olive Oil

While recording a podcast with Ben Greenfield, I was discussing how the French, Tibetan yak …

The Croissant Diet
August 8, 2020Emmy’s Story

Emmy reached out to me and thanked me for publishing The Croissant Diet. She said …

Testimonials, The Croissant Diet
August 6, 2020Feasting Mimicking Diet Trial Results Part 1

I completed the first ten rounds – 20 days – of the Feasting Mimicking Diet …

The Croissant Diet
July 27, 2020Pancake Chicken

Pancake chicken is the second (and final) component of my feast meal during my test …

The Croissant Diet
July 23, 2020Fat Bomb Fries

It’s not by chance that I’m publishing this on July 23rd, 2020, 30 years to …

The Croissant Diet
July 17, 2020The Feasting Mimicking Diet

When I initially published The Croissant Diet (TCD) some said that it wasn’t “very scientific”. …

The Croissant Diet
May 30, 2020Announcing Firebrand Meats Low PUFA Pork CSA

We are pleased to announce the formation of Firebrand Meats! This is a brand new …

Meat Science
March 26, 2020When Life Gives You Pig Heads, Use Them To Boost Your Antioxidant System

I help my friend Devon with catering. He has a pig farm and does pig …

In The Kitchen, Intro To Oxidation, Meat Science
March 25, 2020Oxidative Balance: A Simple Regulatory Loop

For the background material on understanding this post, start with Hydrogen Peroxide Flips The Switch. …

Intro To Oxidation
March 24, 2020Hydrogen Peroxide Flips the Switch

For background information on this post, start by reading the introduction to oixdation. Terms you …

Intro To Oxidation
March 13, 2020Wine Fasting – TCD Redux, Part 2

I knew from the original Croissant Diet trial that fasting was a natural outcome of …

The Croissant Diet
March 6, 2020Stearic Acid Macro-Dosing – TCD Redux, Part 1

Many people have tried The Croissant Diet, or variations of it, since I published the …

In The Kitchen, The Croissant Diet
February 25, 2020Grassfed Beef Suet is an Excellent Source of Stearic Acid

Last summer when I first started experimenting with The Croissant Diet I had breakfast at …

In The Kitchen, Meat Science, The Croissant Diet
February 20, 2020Early Anecdotes – Lowered Blood Glucose and the First-Phase Insulin Response

An oversimplified version of the idea behind The ROS Theory of Obesity is that a …

The Croissant Diet
February 5, 2020The Illustrated Guide And Annotated Guide to The ROS Theory of Obesity

I gave a lecture on The ROS Theory Of Obesity at Interbrook Farm in Sept …

Intro To Oxidation, The ROS Theory of Obesity
January 22, 2020Fat From The Previous Meal Sets The Metabolic Table

After publication of The Croissant Diet, which promotes a diet combining highly saturated fat and …

The Croissant Diet, The ROS Theory of Obesity
January 6, 2020An Alternative Hypothesis For The Rise And Fall of Heart Disease In The US In The 20th Century

OR: An Ode To Vitamin K2 Summary It is still something of a mystery why …

Essays
December 19, 2019Disastrous Trends in American Bacon

In The Croissant Diet specification, I advise against the consumption of pork fat. This is …

Meat Science, The Croissant Diet
December 14, 2019Early TCD Anecdotes – Satiation

I published Introducing The Croissant Diet (TCD) on December 3rd and it’s now the 14th …

The Croissant Diet
December 13, 2019Another Way To Look At Macronutrients

Much of the science behind The Croissant Diet and The ROS Theory Of Obesity is …

The Croissant Diet
December 11, 2019The What’s, Why’s and Where’s of Fat

There are three basic kinds of fat, Saturated Fat (SFA), Monounsaturated Fat (MUFA) and Polyunsaturated …

The Croissant Diet
December 10, 2019New Subreddit for Discussing Hyperlipid/TCD Science and Experimentation r/SaturatedFat

A great spot to post your …

The Croissant Diet
December 3, 2019The Croissant Diet FAQ

Are you serious? Is this some type of ruse or joke? Of course it is!! …

The Croissant Diet
December 3, 2019The Croissant Diet Specification

The specification of The Croissant Diet is a living document. I plan to update it …

The Croissant Diet
December 3, 2019Introducing The Croissant Diet

OR: How I eliminated my spare tire by eating croissants using the six scariest words …

The Croissant Diet
September 27, 2019The Anti-French Diet

Most people seem surprised when I mention that America isn’t actually the fattest place on …

Armchair Epidemiology
September 27, 2019The French Diet In France

The Food and Agriculture Organization of the United Nations (FAO) provides “Food Disappearance” data that …

Armchair Epidemiology
September 26, 2019The French Diet in Upstate New York

In my previous post I defined The French Diet as a diet where the staples …

Armchair Epidemiology
September 26, 2019The French Diet in China

In The ROS Theory of Obesity, I mentioned that the french remained lean in 1970 …

Armchair Epidemiology
September 25, 2019The Curious Case of Nanan and Huain

Another interesting finding of “Diet, Life-style and Mortality in China” is that there was a …

Armchair Epidemiology
September 25, 2019Chinese Office Workers Eat More Than Americans

In The ROS Theory Of Obesity I stated without providing evidence that Chinese people in …

Armchair Epidemiology
September 2, 2019The Three Countries Study

At the beginning of this series I stated that any theory of obesity should be …

The ROS Theory of Obesity
September 2, 2019ROS is Satiation

Satiation is a feeling that is actually triggered in the brain by specific neurons in …

The ROS Theory of Obesity
September 2, 2019The Body Fat of Obese Adults is Highly Unsaturated

This paper measured the level of Stearoyl-CoA desaturase in morbidly obese adults compared to adults …

The ROS Theory of Obesity
September 2, 2019The Loss of SCD1 Prevents Obesity in Mice

A “knockout mouse” is a strain of mice in which a section of their DNA …

The ROS Theory of Obesity
September 2, 2019Butter Causes a High Level of Available Energy 8 Hours After a Meal

When fat cells respond to insulin they take several actions in switching from fat burning …

The ROS Theory of Obesity
September 2, 2019Long Chain Saturated Fat Causes Fat Loss in Mice

If you’ve been reading along you know that by this point we’ve shown that long …

The ROS Theory of Obesity
September 2, 2019The Amount of Polyunsaturated fat in the Modern American Diet Fattens up Mice Without Additional Calories

In this series we’ve discussed the fact that saturated fat oxidation leads to ROS production …

The ROS Theory of Obesity
September 2, 2019Unsaturated Fat Prevents Physiological Insulin Resistance In Humans

This paper studied the effect of a ketogenic diet composed largely of saturated fat compared …

The ROS Theory of Obesity
September 2, 2019Saturated Fat Causes Physiological Insulin Resistance in Humans

In previous posts I have laid out the argument that metabolism of long chain saturated …

The ROS Theory of Obesity
September 2, 2019This Is What Fat Burning Looks Like

In this series I often mention that mitochondrial ROS production creates physiological insulin resistance which …

The ROS Theory of Obesity
September 2, 2019Physiological Insulin Resistance

Let’s think about what happens in response to a starchy meal. Blood sugar rises and …

The ROS Theory of Obesity
September 2, 2019A Highly Conserved Molecular Bottleneck

In the introductory series, we first saw an example of ROS (Reactive Oxygen Species) as …

The ROS Theory of Obesity
September 2, 2019The Mitochondria

A mitochondria works like a battery. It maintains a voltage gradient across its inner-membrane. The …

Intro To Oxidation, The ROS Theory of Obesity
September 2, 2019The ROS Theory of Obesity

AKA The Layperson’s Guide to Hyperlipid This series is going to be exploring the root …

The ROS Theory of Obesity
June 23, 2019Two Elegant Experiments Demonstrating that ROS is The Signal

If you’been reading through the Introduction to Fire in a Bottle series, I explained the …

Intro To Oxidation
June 22, 2019Summary of The Introduction to Life in a Bottle

Oxidation (in a biological context) is the flow of electrons from elements like Hydrogen and …

Intro To Oxidation
June 22, 2019Superoxide: An Unlikely Hero

When I took oncology at Cornell in the mid-90’s, the root cause of cancer was …

Intro To Oxidation
June 18, 2019The Great Oxygenation

The primordial atmosphere of the earth didn’t contain Oxygen (O2). The atmosphere was a “reducing …

Intro To Oxidation
June 18, 2019Meet Your Antioxidant System

In the previous post, we introduced our unlikely hero superoxide, a free radical. We also …

Intro To Oxidation
June 17, 2019Fire In a Bottle

Fire is a positive feedback loop where atmospheric oxygen (O2) oxidizes the hydrocarbon bonds (the …

Intro To Oxidation
June 15, 2019A Very Gentle Introduction to Oxidation

Humans are electrical creatures. Our basic biology is controlled by the movement of electrons. In …

Intro To Oxidation