| Date | Title | Summary | Categories |
|---|---|---|---|
| September 17, 2021 | Campari is a dual bile acid receptor agonist that activates AMPK | I am a huge fan of Italian bitter liqueurs. I was first introduced to the … | Torpor, Sloth and Gluttony |
| September 15, 2021 | AMPK is activated by HIGH cellular energy after a starchy meal | AMPK is a key regulator of metabolic rate and fat burning. The mainline thinking on … | The ROS Theory of Obesity, Torpor, Sloth and Gluttony |
| September 11, 2021 | SCD1 Regulates AMPK and AMPK Regulates SCD1 | So like I was saying, biology is weird. AMPK and SCD1 are a literal teeter … | The SCD1 Theory Of Obesity, Torpor, Sloth and Gluttony |
| September 1, 2021 | AMPK is Kryptonite to the Nuclear Receptor “Superfamily” | Summary Activating AMPK in the livers of mice prevents diet induced obesity despite higher caloric … | Torpor, Sloth and Gluttony |
| September 1, 2021 | Announcing Fire In A Bottle, The Podcast! | That’s right, Brad has a podcast now. In the first episode he tells the story … | Podcasts |
| August 31, 2021 | The AhR is the Keymaster to Torpor | My last posts were viewed by some as pessimistic in a “once you’re obese, you … | Torpor, Sloth and Gluttony |
| August 13, 2021 | Getting Fat Causes You To Overeat | I believe that obesity is a fuel partitioning disorder. I’ve argued that when you pack … | Torpor, Sloth and Gluttony |
| August 13, 2021 | Brad on The Logos Interviews | Brad discusses The ROS Theory of Obesity, torpid metabolisms, PUFAs in meat and more on … | Podcasts |
| August 12, 2021 | PPAR gamma With Oxidized PUFA is the Gatekeeper to Metabolic Inflexibility | In a recent post I talked about three groups of pigs with differing levels of … | Torpor, Sloth and Gluttony |
| July 7, 2021 | Brad on Peak Human podcast | Brad talking about the latest Fire In A Bottle concepts with Brian Sanders. We pack … | Podcasts |
| July 7, 2021 | Brad on The Mr. Bill podcast | Mr Bill’s podcast is not a health-based, typically. This is a great starting point if … | Podcasts |
| July 7, 2021 | Brad on The Natural State with Dr Anthony Gustin | This 2 part podcast is comprehensive look at the topics discussed on Fire In A … | Podcasts |
| July 7, 2021 | Brad Talks Torpor with David Gornoski | This is wide-ranging discussion about the ideas discussed on Fire In A Bottle, including torpor, … | Podcasts |
| June 26, 2021 | Accumulating Linoleic Acid Prevents Diabetes | This is from the EPIC Potsdam study in Germany, which looked at the association between … | Torpor, Sloth and Gluttony |
| June 23, 2021 | Obesity prone pigs go from Normal to Pathological Insulin Sensitivity to Torpor when given enough PUFA | Hap MD asked me if I had any thoughts on Ossabaw pigs. They are interesting … | Torpor, Sloth and Gluttony |
| June 16, 2021 | This Is How Linoleic Acid Makes You Fat, Leptin Resistant and Torpid | I’ve written a lot about the strong correlation between the Desaturase Index (DI) and human … | Torpor, Sloth and Gluttony |
| June 14, 2021 | Bio-Hacking Leptin | I mentioned somewhere that I was leptin resistant somewhere and in the comments of the … | Torpor, Sloth and Gluttony |
| June 10, 2021 | The Cruel Irony of “Eat Less, Move More” | There are many believers in a reductionist calories in, calories out (CICO) view of the … | Torpor, Sloth and Gluttony |
| June 9, 2021 | Leptin Increase Your Metabolic Rate And Keeps You Lean By Making You Inefficient at Walking | Introduction This is part of my Torpor, Sloth and Gluttony series where I will argue … | Torpor, Sloth and Gluttony |
| June 4, 2021 | Sterculia Oil Prevents Liver Fat Accumulation and Prevents Insulin Resistance in Fructose-Fed Rats | In the comments of SCD1 CAUSES Humans to Store Fat, David N posted a link … | The SCD1 Theory Of Obesity |
| June 3, 2021 | David Tillman Shares His Amazing Croissant Diet Story | David has been featured on the blog before under the testimonial David’s Story. He’s lost … | The Croissant Diet |
| May 22, 2021 | Torpor, Sloth and Gluttony: SCD1 CAUSES Humans to Store Fat | Introduction My thesis in this series is that humans get fat NOT from sloth and … | Torpor, Sloth and Gluttony |
| May 22, 2021 | Torpor, Sloth and Gluttony Part 1: Americans ate a LOT in 1939 | Introuction to Torpor, Sloth an Gluttony This is the first post in my new “Sloth … | Torpor, Sloth and Gluttony |
| April 28, 2021 | Female Amazonian forager-horticulturalists have the same metabolic rate as Korean college students. They both eat mostly starch. Their body fat is Saturated. | The title of “High resting metabolic rate among Amazonian forager-horticulturalists experiencing high pathogen burden” makes … | The SCD1 Theory Of Obesity |
| April 15, 2021 | Humans and Hibernating Mammals React to The Same Amount of Dietary Linoleic Acid in the Same Way. By Becoming Torpid. | As a biologist, I always think in evolutionary terms. All mammals share a single ancestor … | The SCD1 Theory Of Obesity, Torpor, Sloth and Gluttony |
| April 14, 2021 | n=1 on Escaping Torpor: Turning off PPAR gamma and turning on Fat Burning | Recently I posted an article recommending combining sterculia oil with berberine and/or fish oil as … | The SCD1 Theory Of Obesity |
| April 9, 2021 | Metabolic Rates In American Men Plunged Between 1919 and 1987 | Introduction If you follow this blog you probably won’t be SHOCKED that I’m following up … | Torpor, Sloth and Gluttony |
| March 29, 2021 | Metabolic Rates in American Women Plunged Between 1919 and 1986 | Intro I have suggested that increased consumption of the Omega 6 polyunsatured fat (PUFA) linoleic … | Torpor, Sloth and Gluttony |
| March 20, 2021 | Sterculia Oil: How to Escape Torpor! | Brad’s Daily Recipe Introduction I’d like to reach my target weight this year or next, … | Sterculia Oil, The SCD1 Theory Of Obesity |
| March 20, 2021 | Sterculia Oil: Metabolic Results Number One | Inroduction So I have a fancy metabolic tester to track my metabolic rate. It’s honestly … | Sterculia Oil, The SCD1 Theory Of Obesity |
| March 20, 2021 | Sterculia Oil: Brad’s Blood Numbers and Safety | Study Design I started my sterculia oil (SO) trial with a 16 week n=1 safety … | Sterculia Oil, The SCD1 Theory Of Obesity |
| March 9, 2021 | Are You In Deep Torpor? SCD1 Theory Of Obesity Summary So Far And Hamsters! | Introduction It’s time for the season finale! Next week I will pivot to discussing my … | The SCD1 Theory Of Obesity |
| March 6, 2021 | Very Long Chain Saturated and Monounsaturated Fats | Overview Very Long Chain Fatty Acids (VLCFA) I’ve become very interested in very long chain … | The SCD1 Theory Of Obesity |
| March 4, 2021 | Membrane Phospholipid Composition of Different Populations | I’ve been promoting the OmagaQuant complete test as a way to calculate your Desaturase Indix … | The SCD1 Theory Of Obesity |
| March 3, 2021 | Good PPAR, Bad PPAR | Overview Introduction I introduced PPAR alpha in Dietary Monounsaturated Fat as an altogether good actor, … | The SCD1 Theory Of Obesity |
| March 1, 2021 | Fat Newborns; Sloth and Gluttony Part 1 | Introduction The most common explanation given for the recent wave of obesity is that “We … | The SCD1 Theory Of Obesity |
| February 26, 2021 | David’s Story | This is a pretty great testimonial to the potential of The Croissant Diet. David really … | Testimonials |
| February 22, 2021 | Really Good Historical Video About The History of SCD1 research Posted at r/SaturatedFat | This was posted by a user of the reddit group r/SaturatedFat. This is a great … | Podcasts |
| February 21, 2021 | Bear Hunting Season; Native Americans Hunted Bear When The PUFA Content Was Lowest | Introduction This is a followup to my post Native Americans Removed Acorn Oil and Replaced … | The SCD1 Theory Of Obesity |
| February 17, 2021 | Lori’s Story | Lori reached out to me wanting to share her story. She initially sent me this … | Testimonials |
| February 15, 2021 | The Body Fat Saturation Of Starch Eaters; Linoleic Acid Dysregulates SCD1 | I’ve argued in The SCD1 Theory of Obesity Part One and Part Two, as well … | The SCD1 Theory Of Obesity |
| February 4, 2021 | Native Americans Removed Acorn Oil and Replaced It With Bear Fat | Introduction In a previous article, I argued that a recent drop in the body temperatures … | The Croissant Diet, The SCD1 Theory Of Obesity |
| February 2, 2021 | Low Carb MD | They really let anyone on podcasts these days! Listen to Brad join obesity clinic doctors … | Podcasts |
| February 2, 2021 | Speed Your Metabolism With Oxidative Stress! Slow It With Antioxidants! | It’s rare to find a scientific paper whose RESULTS are hilarious. Sometimes the authors conclusions … | Intro To Oxidation, The Croissant Diet, The ROS Theory of Obesity, The SCD1 Theory Of Obesity |
| January 30, 2021 | This is Your Body Temperature on Vegetable Oil | Introduction This article suggests that the reason the Tsimane people of Bolivia experienced a significant, … | The Croissant Diet, The SCD1 Theory Of Obesity |
| December 15, 2020 | Brad Talking SCD1 Theory of Obesity with Raphael Sirtoli | World premiere SCD1 … | Podcasts, The SCD1 Theory Of Obesity |
| December 15, 2020 | New List of Additional SCD1 Regulators posted at r/SaturatedFat | There is a great discussion thread for Croissant Diet/ROS Theory of Obesity/SCD1 Theory of Obesity … | The SCD1 Theory Of Obesity |
| December 9, 2020 | Pu’erh Tea is a potent Suppressor of SCD1 | Katie sent me this paper.1 It actually adds an interesting twist to her story that … | The Croissant Diet, The SCD1 Theory Of Obesity |
| December 3, 2020 | Dietary Monounsaturated Fat, The SCD1 Theory of Obesity, Part 3 | Introduction This is the third part of my SCD1 Theory of Obesity series. Here are … | The SCD1 Theory Of Obesity |
| November 16, 2020 | The SCD1 Theory of Obesity Part 2 – The Post Obese Metabolism and What You Can Do About It | AKA The Ros Theory of Obesity Part2, Part 2 Introduction In part 1, I explained … | The SCD1 Theory Of Obesity |
| November 16, 2020 | The SCD1 Theory of Obesity, Part 1 – Insulin, Leptin, SCD1 and Thermogenesis | AKA The ROS Theory of Obesity Part 2, Part 1 Introduction In The ROS Theory … | The SCD1 Theory Of Obesity |
| October 24, 2020 | Brad on Ben Greenfield! | The podcast is out! Excellent chat with Ben. Check it … | Podcasts |
| October 24, 2020 | Brad’s Inflammation Blood Test Numbers – Don’t Conflate Inflammation and ROS! | So I do everything wrong, kind of on purpose. I eat white flour and dairy. … | The Croissant Diet |
| October 21, 2020 | Kirsten’s TCD Post | Kirsten Mortenson, a novelist, posted a nice writeup of her experience with TCD after almost … | Testimonials |
| October 20, 2020 | Podcasts! | I’ve had a busy summer of recording podcasts! There are hours of me blathering on … | Podcasts |
| October 20, 2020 | Katie’s Story | Katie is doing a textbook version of TCD. I love her story, it’s honest and … | Testimonials |
| October 19, 2020 | James’ Story | James posted his success with TCD on Reddit. I reached out to see if he … | Testimonials |
| September 15, 2020 | Butter May Lower LPS Mediated Inflammation Compared to Olive Oil | While recording a podcast with Ben Greenfield, I was discussing how the French, Tibetan yak … | The Croissant Diet |
| August 8, 2020 | Emmy’s Story | Emmy reached out to me and thanked me for publishing The Croissant Diet. She said … | Testimonials, The Croissant Diet |
| August 6, 2020 | Feasting Mimicking Diet Trial Results Part 1 | I completed the first ten rounds – 20 days – of the Feasting Mimicking Diet … | The Croissant Diet |
| July 27, 2020 | Pancake Chicken | Pancake chicken is the second (and final) component of my feast meal during my test … | The Croissant Diet |
| July 23, 2020 | Fat Bomb Fries | It’s not by chance that I’m publishing this on July 23rd, 2020, 30 years to … | The Croissant Diet |
| July 17, 2020 | The Feasting Mimicking Diet | When I initially published The Croissant Diet (TCD) some said that it wasn’t “very scientific”. … | The Croissant Diet |
| May 30, 2020 | Announcing Firebrand Meats Low PUFA Pork CSA | We are pleased to announce the formation of Firebrand Meats! This is a brand new … | Meat Science |
| March 26, 2020 | When Life Gives You Pig Heads, Use Them To Boost Your Antioxidant System | I help my friend Devon with catering. He has a pig farm and does pig … | In The Kitchen, Intro To Oxidation, Meat Science |
| March 25, 2020 | Oxidative Balance: A Simple Regulatory Loop | For the background material on understanding this post, start with Hydrogen Peroxide Flips The Switch. … | Intro To Oxidation |
| March 24, 2020 | Hydrogen Peroxide Flips the Switch | For background information on this post, start by reading the introduction to oixdation. Terms you … | Intro To Oxidation |
| March 13, 2020 | Wine Fasting – TCD Redux, Part 2 | I knew from the original Croissant Diet trial that fasting was a natural outcome of … | The Croissant Diet |
| March 6, 2020 | Stearic Acid Macro-Dosing – TCD Redux, Part 1 | Many people have tried The Croissant Diet, or variations of it, since I published the … | In The Kitchen, The Croissant Diet |
| February 25, 2020 | Grassfed Beef Suet is an Excellent Source of Stearic Acid | Last summer when I first started experimenting with The Croissant Diet I had breakfast at … | In The Kitchen, Meat Science, The Croissant Diet |
| February 20, 2020 | Early Anecdotes – Lowered Blood Glucose and the First-Phase Insulin Response | An oversimplified version of the idea behind The ROS Theory of Obesity is that a … | The Croissant Diet |
| February 5, 2020 | The Illustrated Guide And Annotated Guide to The ROS Theory of Obesity | I gave a lecture on The ROS Theory Of Obesity at Interbrook Farm in Sept … | Intro To Oxidation, The ROS Theory of Obesity |
| January 22, 2020 | Fat From The Previous Meal Sets The Metabolic Table | After publication of The Croissant Diet, which promotes a diet combining highly saturated fat and … | The Croissant Diet, The ROS Theory of Obesity |
| January 6, 2020 | An Alternative Hypothesis For The Rise And Fall of Heart Disease In The US In The 20th Century | OR: An Ode To Vitamin K2 Summary It is still something of a mystery why … | Essays |
| December 19, 2019 | Disastrous Trends in American Bacon | In The Croissant Diet specification, I advise against the consumption of pork fat. This is … | Meat Science, The Croissant Diet |
| December 14, 2019 | Early TCD Anecdotes – Satiation | I published Introducing The Croissant Diet (TCD) on December 3rd and it’s now the 14th … | The Croissant Diet |
| December 13, 2019 | Another Way To Look At Macronutrients | Much of the science behind The Croissant Diet and The ROS Theory Of Obesity is … | The Croissant Diet |
| December 11, 2019 | The What’s, Why’s and Where’s of Fat | There are three basic kinds of fat, Saturated Fat (SFA), Monounsaturated Fat (MUFA) and Polyunsaturated … | The Croissant Diet |
| December 10, 2019 | New Subreddit for Discussing Hyperlipid/TCD Science and Experimentation r/SaturatedFat | A great spot to post your … | The Croissant Diet |
| December 3, 2019 | The Croissant Diet FAQ | Are you serious? Is this some type of ruse or joke? Of course it is!! … | The Croissant Diet |
| December 3, 2019 | The Croissant Diet Specification | The specification of The Croissant Diet is a living document. I plan to update it … | The Croissant Diet |
| December 3, 2019 | Introducing The Croissant Diet | OR: How I eliminated my spare tire by eating croissants using the six scariest words … | The Croissant Diet |
| September 27, 2019 | The Anti-French Diet | Most people seem surprised when I mention that America isn’t actually the fattest place on … | Armchair Epidemiology |
| September 27, 2019 | The French Diet In France | The Food and Agriculture Organization of the United Nations (FAO) provides “Food Disappearance” data that … | Armchair Epidemiology |
| September 26, 2019 | The French Diet in Upstate New York | In my previous post I defined The French Diet as a diet where the staples … | Armchair Epidemiology |
| September 26, 2019 | The French Diet in China | In The ROS Theory of Obesity, I mentioned that the french remained lean in 1970 … | Armchair Epidemiology |
| September 25, 2019 | The Curious Case of Nanan and Huain | Another interesting finding of “Diet, Life-style and Mortality in China” is that there was a … | Armchair Epidemiology |
| September 25, 2019 | Chinese Office Workers Eat More Than Americans | In The ROS Theory Of Obesity I stated without providing evidence that Chinese people in … | Armchair Epidemiology |
| September 2, 2019 | The Three Countries Study | At the beginning of this series I stated that any theory of obesity should be … | The ROS Theory of Obesity |
| September 2, 2019 | ROS is Satiation | Satiation is a feeling that is actually triggered in the brain by specific neurons in … | The ROS Theory of Obesity |
| September 2, 2019 | The Body Fat of Obese Adults is Highly Unsaturated | This paper measured the level of Stearoyl-CoA desaturase in morbidly obese adults compared to adults … | The ROS Theory of Obesity |
| September 2, 2019 | The Loss of SCD1 Prevents Obesity in Mice | A “knockout mouse” is a strain of mice in which a section of their DNA … | The ROS Theory of Obesity |
| September 2, 2019 | Butter Causes a High Level of Available Energy 8 Hours After a Meal | When fat cells respond to insulin they take several actions in switching from fat burning … | The ROS Theory of Obesity |
| September 2, 2019 | Long Chain Saturated Fat Causes Fat Loss in Mice | If you’ve been reading along you know that by this point we’ve shown that long … | The ROS Theory of Obesity |
| September 2, 2019 | The Amount of Polyunsaturated fat in the Modern American Diet Fattens up Mice Without Additional Calories | In this series we’ve discussed the fact that saturated fat oxidation leads to ROS production … | The ROS Theory of Obesity |
| September 2, 2019 | Unsaturated Fat Prevents Physiological Insulin Resistance In Humans | This paper studied the effect of a ketogenic diet composed largely of saturated fat compared … | The ROS Theory of Obesity |
| September 2, 2019 | Saturated Fat Causes Physiological Insulin Resistance in Humans | In previous posts I have laid out the argument that metabolism of long chain saturated … | The ROS Theory of Obesity |
| September 2, 2019 | This Is What Fat Burning Looks Like | In this series I often mention that mitochondrial ROS production creates physiological insulin resistance which … | The ROS Theory of Obesity |
| September 2, 2019 | Physiological Insulin Resistance | Let’s think about what happens in response to a starchy meal. Blood sugar rises and … | The ROS Theory of Obesity |
| September 2, 2019 | A Highly Conserved Molecular Bottleneck | In the introductory series, we first saw an example of ROS (Reactive Oxygen Species) as … | The ROS Theory of Obesity |
| September 2, 2019 | The Mitochondria | A mitochondria works like a battery. It maintains a voltage gradient across its inner-membrane. The … | Intro To Oxidation, The ROS Theory of Obesity |
| September 2, 2019 | The ROS Theory of Obesity | AKA The Layperson’s Guide to Hyperlipid This series is going to be exploring the root … | The ROS Theory of Obesity |
| June 23, 2019 | Two Elegant Experiments Demonstrating that ROS is The Signal | If you’been reading through the Introduction to Fire in a Bottle series, I explained the … | Intro To Oxidation |
| June 22, 2019 | Summary of The Introduction to Life in a Bottle | Oxidation (in a biological context) is the flow of electrons from elements like Hydrogen and … | Intro To Oxidation |
| June 22, 2019 | Superoxide: An Unlikely Hero | When I took oncology at Cornell in the mid-90’s, the root cause of cancer was … | Intro To Oxidation |
| June 18, 2019 | The Great Oxygenation | The primordial atmosphere of the earth didn’t contain Oxygen (O2). The atmosphere was a “reducing … | Intro To Oxidation |
| June 18, 2019 | Meet Your Antioxidant System | In the previous post, we introduced our unlikely hero superoxide, a free radical. We also … | Intro To Oxidation |
| June 17, 2019 | Fire In a Bottle | Fire is a positive feedback loop where atmospheric oxygen (O2) oxidizes the hydrocarbon bonds (the … | Intro To Oxidation |
| June 15, 2019 | A Very Gentle Introduction to Oxidation | Humans are electrical creatures. Our basic biology is controlled by the movement of electrons. In … | Intro To Oxidation |