Brad Marshall

Save Thirty Bucks on Low-PUFA Pork! Pork without seed oils.

Over at Firebrand Meats I sell heirloom berkshire pork that has been raised on a diet that is low in PUFA. Animals cannot make polyunsaturated fat, so if you limit what’s in their diet, you can lower the amount that is in the meat. I summarized the problems with PUFA in pork and poultry in …

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Oxidized Seed Oils Cause Diabetes

This paper from Finland is literally the greatest nutrition paper I’ve ever seen. (Lankinen, 2019) It’s long been known that high plasma levels of linoleic acid predict low diabetes risk. (Kroger, 2010) Furthermore, plasma levels of linoleic acid are a biomarker for intake. At this point people of a certain predisposition will say, “See! I …

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Succinate Increases Athletic Performance By Oxidizing NADH

When I first wrote about the benefits of supplementing with succinate, most of the data available was about long term benefits. Oh sure, it can increase metabolic rate by causing beiging of fat cells. This can help you lose weight over time. And yes, it can have the long term benefit of muscle fiber transition …

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The Onion Of Life. An Evolution Based Framework for Interpreting Molecular Biology (Part 1)

The job of molecular biologists – the ones who discover things like leptin and AMPK and superoxide dismutase – is to figure out the genetics and enzyme pathways behind it all. I’ve worked as a molecular biologist. It’s admittedly been awhile, but I can tell you that they’re very interested in the interactions between enzymes …

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Antioxidants Cause Inflammation

The human body has multiple ways of eliminating the hydrogen peroxide that is generated during metabolism. Glutathione and Thioredoxin rely on a steady stream of NADPH to eliminate the peroxide. This causes the NAD+/NADH pool to become more oxidized due to NADPH being regenerated from NADH by the mitochondrial enzyme NNT. In short, peroxide removal …

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Reductive Stress Causes Oxidative Stress (Take 2)

With every new paper that comes out it becomes clearer that reductive stress is the root cause of oxidative stress. I tried to explain this before, but I’m not sure how well I did. Here’s how it works: Some Initiating Event There is an initiating event which pushes the cell into reductive stress, as defined …

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Sustainable Pork and Metabolic Health in China, featuring Coprophagy: Livestock Agriculture, Part 1

Unless you’ve been living under a rock, you’ve probably noticed that there is controversy surrounding the value of livestock agriculture and its end-products: milk, eggs and meat.   Detractors argue that livestock agriculture is inefficient – livestock eat grain that could be fed to humans.  The condition that the animals live in is inhumane, there is …

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Reductive Stress Gives You The Munchies by Activating D6D

This post comes out a recent conversation I had with Tucker Goodrich and David Gornoski (not live yet, I’ll post it when its out). Tucker was arguing that obesity was caused by endogenous cannabinoids that are made from linoleic acid. I was arguing that obesity is caused by reductive stress. As I pointed out on …

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Reductive stress is the POTENTIAL for oxidative stress

Is it lazy to just post my own tweet and call it an article? You decide. Reducive stress(RS) vs Oxidative stress (OS): they are not opposites, RS is the POTENTIAL for OS. Reduced things (NADH, NADPH, GSH) are electron donors. If they give those electrons to O2 it makes superoxide (O2-). You can't make O2- …

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