I am a huge fan of Italian bitter liqueurs. I was first introduced to the idea when I was working at Memorial Sloan-Kettering in Manhattan. A co-worker brought in a six pack of bitter soda from a local pizza place. I took a sip. It was revolting. My only thought was, “this tastes like bile! …
Campari is a dual bile acid receptor agonist that activates AMPK Read More »
AMPK is a key regulator of metabolic rate and fat burning. The mainline thinking on AMPK often follows the puritanical view of classic obesity research: AMPK senses LOW cellular energy levels by monitoring the ratio of ATP to ADP and AMP.1 This suggests that the best way to stimulate AMPK is by reducing caloric intake. …
AMPK is activated by HIGH cellular energy after a starchy meal Read More »
So like I was saying, biology is weird. AMPK and SCD1 are a literal teeter totter. When SCD1 goes up, AMPK goes down. When AMPK goes up, SCD1 goes down. This matters because, as I pointed out in the last post, AMPK can help to keep us out of torpor. In hibernating animals and obese …
SCD1 Regulates AMPK and AMPK Regulates SCD1 Read More »
Summary Activating AMPK in the livers of mice prevents diet induced obesity despite higher caloric consumption Mice with activated AMPK have lower levels of cytochrome P450 enzymes that produce 12-HETE and 15-HETE – specific activators of PPAR gamma Mice with activated AMPK have higher rates of both fat and glucose metabolism AMPK blocks the pathway …
AMPK is Kryptonite to the Nuclear Receptor “Superfamily” Read More »
That’s right, Brad has a podcast now. In the first episode he tells the story of the squirrel and the acorn, what makes acorns so uniquely fattening and how Native Americans knew to avoid acorn oil! And it’s funny! Available on Spotify, Apple Podcasts or wherever you listen to podcasts.
My last posts were viewed by some as pessimistic in a “once you’re obese, you are stuck” kind of way. I don’t believe that and very soon I will start writing about solutions. Having said that, this post will perhaps seem pessimistic if you thought the previous ones were. I’m working through the basic mechanisms …
The AhR is the Keymaster to Torpor Read More »
I believe that obesity is a fuel partitioning disorder. I’ve argued that when you pack on fat, you essentially “lose” that fuel into your fat tissue. If you don’t have access to fuel, you become hungry and you eat more. In my last article, I started to delve into the mechanism of this. One thing …
Getting Fat Causes You To Overeat Read More »
Brad discusses The ROS Theory of Obesity, torpid metabolisms, PUFAs in meat and more on The Logos Interviews Podcast with Sebastian Lenk.
In a recent post I talked about three groups of pigs with differing levels of insulin sensitivity. Group 1 was fed a low fat diet and remained insulin sensitive. Group 2 was given 40% of calories as a special soybean oil blend with the triply unsaturated alpha-linolenic acid (ALA) largely removed. These pigs became what …
PPAR gamma With Oxidized PUFA is the Gatekeeper to Metabolic Inflexibility Read More »
Brad talking about the latest Fire In A Bottle concepts with Brian Sanders. We pack in a lot of info in under 2 hours!
Mr Bill’s podcast is not a health-based, typically. This is a great starting point if you you’re looking for a podcast about Fire In A Bottle concepts with little technical background.
This 2 part podcast is comprehensive look at the topics discussed on Fire In A Bottle to date. Part One. Part Two.
This is wide-ranging discussion about the ideas discussed on Fire In A Bottle, including torpor, SCD1 and Sterculia Oil.
This is from the EPIC Potsdam study in Germany, which looked at the association between membrane phospholipid composition, diet and type 2 diabetes risk.1 Read it and weep. It looks like linoleic acid prevents diabetes after all. Time to shut down the blog, run out and buy some corn oil. KIDDING! Remember what happened to …
Accumulating Linoleic Acid Prevents Diabetes Read More »
Hap MD asked me if I had any thoughts on Ossabaw pigs. They are interesting because they are one of the only animals other than humans who spontaneously have heart attacks (the only?). Ossabaw piings are descended from Spanish pigs that were dropped on Ossabaw island off of the coast of Georgia, United States, in …
