The AhR Actively Manages the Gut Microbiome for Fatness

People think about the gut microbiome as something that is passively managed. Eat some fiber and pro-biotics and hopefully it will grow and bloom. Whose microbiome is it anyway? Obesity Explained, Episode 5. Watch the video version below if you prefer: Hibernators adjust their microbiome to fatten In the case of hibernating mammals, it is …

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Torpor, Circadin Rhythms and the AhR: Obesity Explained, Episode 4

Episode 4 of Obesity Explained is out! Watch The Video! Video Summary It’s January. Days are short, the light is dim. This one is about circadian rhythms, daylength, body weight and torpor. My working hypothesis is that the Aryl Hydrocarbon Receptor is A, if not THE, master regulator of torpor. Kynurenine is a tryptophan metabolite …

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Saturated Fat is in the Eye of the Beholder; also Ants and Torpor

I wanted to make a quick post to point out a real bias in the literature about how the phrase “saturated fat” is used. Lard is always referred to as saturated fat. Never mind that it’s always less than 50% saturated. I also wanted to apologize for not getting around to make summary posts of …

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Save Thirty Bucks on Low-PUFA Pork! Pork without seed oils.

Over at Firebrand Meats I sell heirloom berkshire pork that has been raised on a diet that is low in PUFA. Animals cannot make polyunsaturated fat, so if you limit what’s in their diet, you can lower the amount that is in the meat. I summarized the problems with PUFA in pork and poultry in …

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Oxidized Seed Oils Cause Diabetes

This paper from Finland is literally the greatest nutrition paper I’ve ever seen. (Lankinen, 2019) It’s long been known that high plasma levels of linoleic acid predict low diabetes risk. (Kroger, 2010) Furthermore, plasma levels of linoleic acid are a biomarker for intake. At this point people of a certain predisposition will say, “See! I …

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Succinate Increases Athletic Performance By Oxidizing NADH

When I first wrote about the benefits of supplementing with succinate, most of the data available was about long term benefits. Oh sure, it can increase metabolic rate by causing beiging of fat cells. This can help you lose weight over time. And yes, it can have the long term benefit of muscle fiber transition …

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The Onion Of Life. An Evolution Based Framework for Interpreting Molecular Biology (Part 1)

The job of molecular biologists – the ones who discover things like leptin and AMPK and superoxide dismutase – is to figure out the genetics and enzyme pathways behind it all. I’ve worked as a molecular biologist. It’s admittedly been awhile, but I can tell you that they’re very interested in the interactions between enzymes …

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Antioxidants Cause Inflammation

The human body has multiple ways of eliminating the hydrogen peroxide that is generated during metabolism. Glutathione and Thioredoxin rely on a steady stream of NADPH to eliminate the peroxide. This causes the NAD+/NADH pool to become more oxidized due to NADPH being regenerated from NADH by the mitochondrial enzyme NNT. In short, peroxide removal …

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Reductive Stress Causes Oxidative Stress (Take 2)

With every new paper that comes out it becomes clearer that reductive stress is the root cause of oxidative stress. I tried to explain this before, but I’m not sure how well I did. Here’s how it works: Some Initiating Event There is an initiating event which pushes the cell into reductive stress, as defined …

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Sustainable Pork and Metabolic Health in China, featuring Coprophagy: Livestock Agriculture, Part 1

Unless you’ve been living under a rock, you’ve probably noticed that there is controversy surrounding the value of livestock agriculture and its end-products: milk, eggs and meat.   Detractors argue that livestock agriculture is inefficient – livestock eat grain that could be fed to humans.  The condition that the animals live in is inhumane, there is …

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