Reductive Stress Gives You The Munchies by Activating D6D

This post comes out a recent conversation I had with Tucker Goodrich and David Gornoski (not live yet, I’ll post it when its out). Tucker was arguing that obesity was caused by endogenous cannabinoids that are made from linoleic acid. I was arguing that obesity is caused by reductive stress. As I pointed out on …

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Reductive stress is the POTENTIAL for oxidative stress

Is it lazy to just post my own tweet and call it an article? You decide. Reducive stress(RS) vs Oxidative stress (OS): they are not opposites, RS is the POTENTIAL for OS. Reduced things (NADH, NADPH, GSH) are electron donors. If they give those electrons to O2 it makes superoxide (O2-). You can't make O2- …

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How Stearic Acid Battles Reductive Stress; The Banana Milkshake Study Redux

Since I published The Croissant Diet there has been much interest in the scientific article I call “The banana milkshake study“​1​. The study showed that ingestion of 24g of stearic acid in a banana shake after a two day low fat diet caused mitochondrial fusion and a drop in circulating acylcarnitines. We are very interested …

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PUFA as an obesogen; How Seed Oils Cause Reductive Stress, Part VI

Obesogens are environmental toxins that make you fat. A commonality among them is that they activate receptors such as hormone receptors, androgen receptors, and perhaps most importantly, receptors in the nuclear receptor superfamily. Of course, if certain chemicals can make you fat, you have to really question the calories-in-calories-out theory of obesity. Certain chemicals can …

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Seed oils make lean people behave like fat people, metabolically speaking; How seed oils cause reductive stress, part V

In this series, I have argued that consuming seed oils causes reductive stress in the mitochondria as defined by high levels of acetyl-CoA and NADH. You could also call this “too much fuel” in the mitochondira, AKA a flooded engine. If I am correct, it should be easy to demonstrate in the short term that …

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Carbon Recycling: What Happens to Seed Oils When You Eat Them? ; How Seed Oils Cause Reductive Stress, Part IV

In this series I’ve been using the analogy of a flooded engine to help to understand some pretty complicated dynamics that happen in the mitochondria when we burn fat.  The details can be overwhelming but the high-level perspective is pretty straightforward.  If you fill the mitochondria with too much fuel and not enough oxygen, the …

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Dietary Linoleic Acid Does Not Reduce Diabetes Risk

Introduction In a recent Twitter thread, Simon Hill, MSc. BSc. tweeted this about a recent podcast episode of The Proof featuring Bill Harris, PhD. Did you listen to the debate on my show? Omega 6 being a driver of CHD is a very hard position to take. — Simon Hill MSc, BSc (Hons) (@theproof) June …

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Acetylation Turns on Lipogenic Enzymes; How Seed Oils Cause Reductive Stress, Part III

I argued in part II of this series that consumption of unsaturated fats fails to create a properly oxygenated fuel mix, which leads to a rise in mitochondrial acetyl-CoA and NADH levels along with a drop in NAD+ levels. This is reductive stress. The system that replenishes NAD+ while burning fat is the production and …

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The Mitochondrial Bottleneck as the carburetor screw; How seed oils cause reductive stress, part II

In part I of this series I introduced the analogy of reductive stress as a flooded engine.  If there is too much fuel and not enough air, an engine will flood.  Elevated circulating acylcarnitines in obesity are analogous to black smoke out of the tailpipe of a flooded engine – unburnt fuel spewing back out …

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The Flooded Engine, An Analogy; How Seed Oils Cause Reductive Stress, Part I

I’ve been writing a lot about reductive stress and its role at the heart of both oxidative stress and obesity.  I’m aware that the term reductive stress isn’t terribly intuitive.  It’s a wonky, scientific term and calling it “the opposite of oxidative stress” really does little to aid in understanding for non-redox scientists.    I’ve been …

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CD38 links obesity, bacterial-induced inflammation, and reductive stress

The idea of this series is that the underlying condition that drives obesity forward is reductive stress, as defined by the NAD+/NADH ratio being too low (not enough NAD+).  CD38 is a membrane bound enzyme, expressed in most tissues, that increases throughout life, steadily reducing NAD+ levels​1​.  It is the body’s “primary NADase”, the main …

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The Pro-oxidant Alpha Lipoic Acid makes you lean, Antioxidants make you fat (sometimes)

The WebMD entry on alpha lipoic acid (ALA) begins with, “Alpha-lipoic acid is an antioxidant”.  ALA can in certain situations act as an antioxidant, but in general it does not act as an antioxidant.  If you read my article about antioxidants you’ll know that in a redox reaction, when one thing in a reaction is …

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