People think about the gut microbiome as something that is passively managed. Eat some fiber and pro-biotics and hopefully it will grow and bloom. Whose microbiome is it anyway? Obesity Explained, Episode 5. Watch the video version below if you prefer: Hibernators adjust their microbiome to fatten In the case of hibernating mammals, it is …
The AhR Actively Manages the Gut Microbiome for Fatness Read More »
Episode 4 of Obesity Explained is out! Watch The Video! Video Summary It’s January. Days are short, the light is dim. This one is about circadian rhythms, daylength, body weight and torpor. My working hypothesis is that the Aryl Hydrocarbon Receptor is A, if not THE, master regulator of torpor. Kynurenine is a tryptophan metabolite …
Torpor, Circadin Rhythms and the AhR: Obesity Explained, Episode 4 Read More »
I wanted to make a quick post to point out a real bias in the literature about how the phrase “saturated fat” is used. Lard is always referred to as saturated fat. Never mind that it’s always less than 50% saturated. I also wanted to apologize for not getting around to make summary posts of …
Saturated Fat is in the Eye of the Beholder; also Ants and Torpor Read More »
Over at Firebrand Meats I sell heirloom berkshire pork that has been raised on a diet that is low in PUFA. Animals cannot make polyunsaturated fat, so if you limit what’s in their diet, you can lower the amount that is in the meat. I summarized the problems with PUFA in pork and poultry in …
Save Thirty Bucks on Low-PUFA Pork! Pork without seed oils. Read More »
This paper from Finland is literally the greatest nutrition paper I’ve ever seen. (Lankinen, 2019) It’s long been known that high plasma levels of linoleic acid predict low diabetes risk. (Kroger, 2010) Furthermore, plasma levels of linoleic acid are a biomarker for intake. At this point people of a certain predisposition will say, “See! I …
Oxidized Seed Oils Cause Diabetes Read More »
By popular demand! This is clipped from my recent longer video Seed Oil and Fryer Oil Reality. This one is only 10 minutes and is just the parts of the video where I talk about what happens in restaurant deep fryers. Enjoy!
I made this video about the realities of seed oils and fryer oils. This started as a reaction video to Are Seed Oils Inflammatory by Gil Carvalho, MD PhD on his Nutrition Made Simple channel. I think it evolved into a pretty interesting discussion on the seed oil topic. Perhaps I’m biased. The main parts …
Seed Oil and Fryer Oil Reality Video. D6D. Read More »
When I first wrote about the benefits of supplementing with succinate, most of the data available was about long term benefits. Oh sure, it can increase metabolic rate by causing beiging of fat cells. This can help you lose weight over time. And yes, it can have the long term benefit of muscle fiber transition …
Succinate Increases Athletic Performance By Oxidizing NADH Read More »
The job of molecular biologists – the ones who discover things like leptin and AMPK and superoxide dismutase – is to figure out the genetics and enzyme pathways behind it all. I’ve worked as a molecular biologist. It’s admittedly been awhile, but I can tell you that they’re very interested in the interactions between enzymes …
The human body has multiple ways of eliminating the hydrogen peroxide that is generated during metabolism. Glutathione and Thioredoxin rely on a steady stream of NADPH to eliminate the peroxide. This causes the NAD+/NADH pool to become more oxidized due to NADPH being regenerated from NADH by the mitochondrial enzyme NNT. In short, peroxide removal …
Antioxidants Cause Inflammation Read More »
People talk about calories-in, calories-out. It is the idea that weight will be gained if you eat extra calories or lost if you burn extra calories, say by exercising. Many studies have been done and calorie restriction or exercise for weight loss and the results are very: these are losing strategies. In this video I …
Electrons-In, Electrons-Out Read More »
I was responding to an email from someone who grazes hogs in a oak forest. They wondered about the effect this would have on the linoleic acid content of their pork. As I was responding, I thought that this was an email a lot of people might like to read, so I am posting a …
Lioleic Acid Effects From Acorn Grazed Hogs Read More »
This video is a supplement to the post Reductive Stress Causes Oxidative Stress (Take 2). You can find the citations there.
With every new paper that comes out it becomes clearer that reductive stress is the root cause of oxidative stress. I tried to explain this before, but I’m not sure how well I did. Here’s how it works: Some Initiating Event There is an initiating event which pushes the cell into reductive stress, as defined …
Reductive Stress Causes Oxidative Stress (Take 2) Read More »
Unless you’ve been living under a rock, you’ve probably noticed that there is controversy surrounding the value of livestock agriculture and its end-products: milk, eggs and meat. Detractors argue that livestock agriculture is inefficient – livestock eat grain that could be fed to humans. The condition that the animals live in is inhumane, there is …
