Where are we now? We are in a shallow sea. The time is seven hundred fifty million years ago. Ish. (750MYAish) There is no coffee, don’t bother looking. Land plants don’t exist yet. We have started to wriggle. Wriggling requires a left and right hand side. You need to be a bilaterian. Your FACE is …
Cells in the first weeks of embryo growth are in a hpyoxic enviroment and they are glyolytic. Glycolysis does not consume oxygen. As oxygen levels in the placenta slowly increase over the weeks, the cells rely more on mitochondrial oxidative metabolism. This is called oxidative phophorylation or OxPhos because the process consumes oxygen and the …
When the clever mammals decided to grow the next generation in their placentas (except for the stupid monotremes), they remembered their copepod friends who vertically migrate to the Oxygen Minimum Zone so that they can fatten. If you want the fuel to build up you need to close the damper. An initiating event in pregnancy …
I’m a country boy and I grew up around woodstoves. If you want the fire to last all night – if you want the fuel to burn slowly – what you do is you close the damper to almost nothing. If you do that there will still be a half or three-quarter of the way …
In the early spring of 2024 I opened my front door and startled a very fat woodchuck, known as whistle pigs to some country types due to the fact that they are fat like pigs and make a whistling sound when they run, who for whatever reason was under my front steps. As I am …
The Whistle Pig and the Hare: Fattening Is A Biological Choice Read More »
ExFatLoss recently posted an article where he said that he had taken the “gold standard” test of metabolic rate using the “Doubly Labelled Water” method. His results seem a bit suprising. The test says he is burning a bit north of 4600 calories per day whereas he claims to be eating around 2800 calories per …
Doubly Labelled Water is Less Useful For Weirdos Read More »
New year, new me! I think they say that. Anyhoo, there’s been a lot of discussion of macros in the last year, with me going on about the redox advantages of carbohydrates and that studies in mice show that branched-chain amino acid restriction reverses obesity. So I thought I’d start the year by putting fresh …
Did you know that your body fat composition is a signal to your metabolism? Should you be fattening up for winter? Do you live in a land of eternal summer? Your body turns fat into ethanolamides which act as signaling molecules. Arachidonic acid as a signalling molecule is called AEA (arachidonoylethanolamide). AEA is an endocannabinoid, …
Here’s the primer of essential videos that Paul and I discussed. The Emergence Diet In 12 Minutes How Olive Makes You Fat The Reality Of Metabolic Health In The Mediterranean Why Aren’t The Inuit In Ketosis The History Of Body Fat Composition Insect Fat As A Signal How To Fatten A Mammal The Redox Case …
Videos Mentioned In My Interview With Paul Saladino, MD Read More »
I’ve been advocating reducing protein intake, and particularly reducing consumption of the the branched chain amino acids (BCAA) isoleucine, leucine and valine. The goal of the protein restriction is to increase insulin sensitivity to aid in weight loss. For years I’ve struggled with fasting blood glucose in the prediabetic range (115-120). This morning my fasting …
MCT oil has long been associated with weight loss. This is especially true of the 8 carbon MCT, caprylic acid. I have yet to see any reasonably definitive reason for why this might be. I have recently been talking about restriction of branched-chain amino acids (BCAAs: valine, leucine and especially isoleucine) for weight loss. Obese …
I’ve argued that obesity, diabetes and heart disease are the human expression of mammalian torpor, an altered metabolic state characterized by high levels of desaturase enzymes and high circulating branched chain amino acids (BCAAs): leucine, isoleucine and valine. A torpid mammal prefers to store fat rather than burn it. Two 2023 papers add significant evidence …
Human Metabolic Syndrome Resembles Mammalian Torpor (New Evidence) Read More »
So I’ve been promising that I would share my weight progress after I had done The Emergence Diet for 28 days. My argument is that weight loss isn’t about calories, it’s about burning glucose efficiently. To burn fat you need NAD+. Burning fat lowers NAD+ availability and burning carbohydrate increases it. “Fat burns in the …
I’ve been consuming what I’m now calling the “induction phase” of the Emergence Diet. In short, this is a very high carbohydrate (>400g/day) diet that is low in fat and which the protein source is mainly collagen based proteins: bone broth, gelatin, headcheese, pork rinds, pigs feet, beef tendon, etc. I am also supplementing with …
How I Both Aced and Failed My Oral Glucose Tolerance Test (OGTT) Read More »
This video serves as a sort of road map of Fire In A Bottle topics. On the blog and video series I’ve drilled into numerous topics and their relationship with obesity: PUFA, MUFA, The ROS Theory of Obesity, reductive stress, D6D, SCD1, the AhR, PPAR alpha, etc. Sometimes it’s useful to zoom out and see …
