Brad on Peak Human podcast
Brad talking about the latest Fire In A Bottle concepts with Brian Sanders. We pack in a lot of info in under 2 hours!
Brad on The Mr. Bill podcast
Mr Bill’s podcast is not a health-based, typically. This is a great starting point if you you’re looking for a podcast about Fire In A Bottle concepts with little technical background.
Brad on The Natural State with Dr Anthony Gustin
This 2 part podcast is comprehensive look at the topics discussed on Fire In A Bottle to date. Part One. Part Two.
Brad Talks Torpor with David Gornoski
This is wide-ranging discussion about the ideas discussed on Fire In A Bottle, including torpor, SCD1 and Sterculia Oil.
Accumulating Linoleic Acid Prevents Diabetes
This is from the EPIC Potsdam study in Germany, which looked at the association between membrane phospholipid composition, diet and type 2 diabetes risk.​1​ Read it and weep. It looks like linoleic acid prevents diabetes after all. Time to shut down the blog, run out and buy some corn oil. KIDDING! Remember what happened to …
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Obesity prone pigs go from Normal to Pathological Insulin Sensitivity to Torpor when given enough PUFA
Hap MD asked me if I had any thoughts on Ossabaw pigs. They are interesting because they are one of the only animals other than humans who spontaneously have heart attacks (the only?). Ossabaw piings are descended from Spanish pigs that were dropped on Ossabaw island off of the coast of Georgia, United States, in …
This Is How Linoleic Acid Makes You Fat, Leptin Resistant and Torpid
I’ve written a lot about the strong correlation between the Desaturase Index (DI) and human obesity. DI is an indirect indicator of the activity of the SCD1 gene. I have also suggested that the consumption of linoleic acid – the primary Omega 6 polyunsaturated fat (PUFA) in the human diet found in vegetable oil, bacon …
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Bio-Hacking Leptin
I mentioned somewhere that I was leptin resistant somewhere and in the comments of the blog someone asked how I knew that I was. My immediate response was, “because I’m fat.” But also, “because I have a high desaturase index (DI), indicating high activity of the enzyme SCD1.” A high DI is an indicator that …
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The Cruel Irony of “Eat Less, Move More”
There are many believers in a reductionist calories in, calories out (CICO) view of the world. People in this tribe often say things like, “to lose weight, you just have to eat less and move more.” I want to be clear, I believe in calories in, calories out from a strict thermodynamic perspective. Calories you …
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Leptin Increase Your Metabolic Rate And Keeps You Lean By Making You Inefficient at Walking
Introduction This is part of my Torpor, Sloth and Gluttony series where I will argue that obesity is caused not by sloth and gluttony but by specific metabolic processes. Leptin is a hormone produced by fat cells. The fatter one gets, the more circulating leptin one has. Leptin is the master hormone whose job is …
Sterculia Oil Prevents Liver Fat Accumulation and Prevents Insulin Resistance in Fructose-Fed Rats
In the comments of SCD1 CAUSES Humans to Store Fat, David N posted a link to a paper​​1​ that I referenced in The SCD1 Theory of Obesity Part Two where liver fat accumulation and insulin resistance in rats fed a high fructose diet were prevented by supplementing with sterculia oil. I hadn’t looked at the …
David Tillman Shares His Amazing Croissant Diet Story
David has been featured on the blog before under the testimonial David’s Story. He’s lost 40 lbs on a strict version of The Croissant Diet in 7 months while eating 5 pints of Haagen-Dazs per week, as well as croissant sandwiches and cheeseburgers. David had tried keto and vegan diets in the past with less …
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Torpor, Sloth and Gluttony: SCD1 CAUSES Humans to Store Fat
Introduction My thesis in this series is that humans get fat NOT from sloth and gluttony, human characteristics wrapped in morality and asceticism. They in fact get fat from torpor, an underlying metabolic change triggered by consuming linoleic acid. In my previous article I introduced the concepts of this series as well as the idea …
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Torpor, Sloth and Gluttony Part 1: Americans ate a LOT in 1939
Introuction to Torpor, Sloth an Gluttony This is the first post in my new “Sloth and Gluttony” series where I will be arguing that the obesity epidemic was NOT caused by billions of people around the globe simultaneously becoming slothful and gluttonous. I will argue that in fact the reasons are biological and evolutionarily conserved. …
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Female Amazonian forager-horticulturalists have the same metabolic rate as Korean college students. They both eat mostly starch. Their body fat is Saturated.
The title of “High resting metabolic rate among Amazonian forager-horticulturalists experiencing high pathogen burden” makes it unambiguous as to the authors feelings about why the Tsimane have high metabolic rates. They include this graph to show just how unique the Tsimane are. I recently wrote about the plunge in American Metabolic rates in women between …