In this series we’ve discussed the fact that saturated fat oxidation leads to ROS production in the mitochondria which makes peripheral fat cells “physiologically insulin resistant” which prevents them from switching from fat burning to fat storage. We’ve shown that saturated fat reversibly induces insulin resistance in people in the short term and that a …
This paper studied the effect of a ketogenic diet composed largely of saturated fat compared to one composed largely of unsaturated fat. Ketogenic diets are high in fat and low in carbohydrate and protein. Ketogenic diets are known to stimulate physiological insulin resistance that goes away after a few days of eating a carbohydrate rich …
Unsaturated Fat Prevents Physiological Insulin Resistance In Humans Read More »
In previous posts I have laid out the argument that metabolism of long chain saturated fat creates mitochondrial ROS which causes short term insulin resistance while the saturated fat is oxidized. Insulin tells the bodies cells to switch from fat metabolism to glucose metabolism and causes fat cells to absorb glucose, convert it to fat …
Saturated Fat Causes Physiological Insulin Resistance in Humans Read More »
In this series I often mention that mitochondrial ROS production creates physiological insulin resistance which keeps your cells in “fat burning mode”. In this paper, the authors actually took a picture of fat burning mode!! They asked human subjects to eat a low fat vegan diet for two days and then gave them a banana …
Let’s think about what happens in response to a starchy meal. Blood sugar rises and insulin is released. Insulin attaches to the insulin receptors on the cell membranes of muscle cells, fat cells, etc. The cells respond by moving a glucose transporter, GLUT4, into the cell membrane so that they can start importing glucose. Insulin …
In the introductory series, we first saw an example of ROS (Reactive Oxygen Species) as a signal in a small worm (nematode) called c. elegans. When glucose oxidation in c. elegans is blocked, the worms shift to burning fat which creates more ROS which ultimately leads to a longer lifespan for the worm. Why does …
A mitochondria works like a battery. It maintains a voltage gradient across its inner-membrane. The outside of the membrane has a positive charge and the inside has a negative charge. Protons from the outside flow back through the membrane down the gradient, releasing energy, through a large cross-membrane protein complex called ATP synthase, which uses …
AKA The Layperson’s Guide to Hyperlipid This series is going to be exploring the root cause of obesity and how energy balance is controlled at a cellular level. My thinking on this subject has been heavily influenced by Peter at Hyperlipid and his protons theory. His writing is dense, technical and full of acronyms. I …
