The ROS Theory of Obesity

Unsaturated Fat Prevents Physiological Insulin Resistance In Humans

This paper studied the effect of a ketogenic diet composed largely of saturated fat compared to one composed largely of unsaturated fat. Ketogenic diets are high in fat and low in carbohydrate and protein. Ketogenic diets are known to stimulate physiological insulin resistance that goes away after a few days of eating a carbohydrate rich …

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Saturated Fat Causes Physiological Insulin Resistance in Humans

In previous posts I have laid out the argument that metabolism of long chain saturated fat creates mitochondrial ROS which causes short term insulin resistance while the saturated fat is oxidized. Insulin tells the bodies cells to switch from fat metabolism to glucose metabolism and causes fat cells to absorb glucose, convert it to fat …

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Physiological Insulin Resistance

Let’s think about what happens in response to a starchy meal. Blood sugar rises and insulin is released. Insulin attaches to the insulin receptors on the cell membranes of muscle cells, fat cells, etc. The cells respond by moving a glucose transporter, GLUT4, into the cell membrane so that they can start importing glucose. Insulin …

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The Mitochondria

A mitochondria works like a battery. It maintains a voltage gradient across its inner-membrane. The outside of the membrane has a positive charge and the inside has a negative charge. Protons from the outside flow back through the membrane down the gradient, releasing energy, through a large cross-membrane protein complex called ATP synthase, which uses …

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