Electrons-In, Electrons-Out

People talk about calories-in, calories-out. It is the idea that weight will be gained if you eat extra calories or lost if you burn extra calories, say by exercising.

Many studies have been done and calorie restriction or exercise for weight loss and the results are very: these are losing strategies.

In this video I take a look at why tracking electrons is much more useful than tracking calories. These mice got fat. Not because they were lazy, not be cause they overate. They got fat because they lost the mechanism that creates electrons out.

I’ve written about this study here.

Li, Y., Mouche, S., Sajic, T., Veyrat-Durebex, C., Supale, R., Pierroz, D., Ferrari, S., Negro, F., Hasler, U., Feraille, E., Moll, S., Meda, P., Deffert, C., Montet, X., Krause, K.-H., & Szanto, I. (2012). Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity. In International Journal of Obesity (Vol. 36, Issue 12, pp. 1503–1513). Springer Science and Business Media LLC. https://doi.org/10.1038/ijo.2011.279

7 thoughts on “Electrons-In, Electrons-Out”

  1. Hi Brad,
    what is the role of protons and protonophores in obesity?
    I read somewhere that stearic acid is a protonophore!

    1. Hi Bill!

      It’s funny you use that word, I’ve been reading a lot about UCP3 which uses long chain fats as protonophores.


      “Unsaturated (C18–20) FFAs are the most active
      uncouplers. Uncoupling activity with the best unsaturated FFA
      (linoleic C18:2) is 2.7-fold higher than with the best saturated FFA
      (palmitic C16:0). Among saturated FFAs, the potency to reduce ΔΨ
      and to stimulate resting respiration decreases with decreasing carbon
      chain length (except for stearic acid C18:0, which is slightly active).
      Palmitic (C16:0) and myristic (C14:0) acids are quite effective as
      uncouplers, while capric (10:0) and caprylic (8:0) acids are almost

  2. Hi Brad,

    Reading your recent articles and videos on the flow of electrons & metabolism has raised some curiosity from my part on which type of water would be the best choice.

    Bottled Mineral Water vs. Reverse Osmosis vs. Ionized Alkaline Water.

    Mineral water is the natural form of water, but as it is usually coems in plastic bottles I was wondering if ionized water would be best as you also get all the minerals & water from a cleaner source.

    However, I don´t exactly understand how it would impact the electron & NAD/NADH balance in the body.

    Do you have a take on this?


    1. Bottled mineral water seems like a good choice. You won’t get any nuclear receptor activation from the plastic and calcium and magnesium is important! I drink well water.

Comments are closed.