I told the story of Sandra in Obesity as a Global Succinate Dehydrogenase Activity Deficit. I asked her to be a guinea pig and she was happy to share data. This is her story of her n=1 trial using Succin-ade for a month. The “supplements” she mentions and vitamin D3 and K2 plus the polyphenols resveratrol and myricetin. If I could start the trial over again, I would have had her take a-lipoic acid (“alpha lipoic”) instead of resveratrol and myricetin. She did fine anyway!
She used a scoop of the Succin-ade two to three times a day with meals. That’s about 10-15g of actual succin-ate – 40-60 calories (assuming 4cal/g), which is in the range of the 1.5-2% that caused weight loss in mice. 2% of a 2400 calorie diet is 48 calories. Another way of looking at it is that 15g of supplementary succinate would be the equivalent of swapping out around 36g of oleic acid (MUFA) with 36g of stearic acid (saturated fat), from an FADH2:NADH ratio perspective. One gran of succinate would replace 2.4g of FADH2 input from oleic acid.
I’ve put Sandra’s raw data at the end. As you can see, she had a significant rise in body temperature alongside the weight loss. She was doing thermogenesis! This is her story in her words.
Hi. I am Sandra, a 48 year-old educator from Ithaca. I lost 10 pounds and 3 inches off my waist in a month of using Succin-ade.
After more than a year on Zoom and majorly reinventing how I do my job while remote working and being stuck inside, my physical activity diminished and my wine consumption increased… did I mention that I am an educator? Needless to say, I gained the “Covid 19.”
In the past, I have done the Paleo 30-Day Challenge and that had great results, but I was cooking ALL OF THE TIME and could not sustain that plan. How I eat now is fairly decent normally – mostly protein, veggies, and cheese… and wine. The hardest part of sticking with anything is my chaotic schedule – no one day is ever the same. Easy foods have become my life.
The easy part of using the Succin-ade, vitamins, and supplements was the morning. A scoop with some water that washed down the pills. Eat breakfast and had my coffee. Breakfast is usually a gluten free bagel with cream cheese and lox. Sometimes its an omelet with ground beef, veggies and cheese.
Lunch is usually some sort of meat and veggie combo – anything starchy makes me sleepy. Sometimes I will have rice noodles, they’re not so bad. If I am working from home, I will tend to have a larger lunch at a later time and will take the Succin-ade and supplements before I eat. Dinner always ends up being cheese and crackers and wine on those nights!
When working at school, I bring in a keto frozen meal for ease. I don’t bring the Succin-ade set up to work – it’s bad enough trying to remember to put on my mask every time I have to step out of my office.
Due to my insane schedule, a lot of my dinners have been pizza which I make from frozen gluten free crusts and any combo of cheese, meats, and veggies. Easy and satisfying… especially late at night. My other go-to easy meals are Annie’s gluten free Mac and Cheese with extra cheese (and sometimes made a little healthier with spinach or broccoli). And recently I have been getting a rotisserie chicken and a bunch of cooked seasoned veggies from the prepared food section of the grocery store. Easy plates to throw together and nuke. I’ll do the Succin-ade and supplements along with my wine as I’m making dinner.
I can cook for real, I swear. I just don’t want to clean up after.
During this time I have also been unable to exercise due to an injury – so it was doubly impressive to see the weight loss in a month when I haven’t broken a sweat.
I’m going to keep it going and hope to see results as I am healing and can start being active again.
|Day||Weight Change||Waist Change||Body Temp|
|5||-6||0||97.1||Added Vit D & K2|
|13||-6||0||97.9||Added Resveratorl + Myricetin|
|18||-11||-2||98.4||Took a break|
|19||-11||-2||98.6||Took a break|