A Google Scholar search for the phrase “oxidative stress diabetes” currently yields over 500,000 papers, but the phrase “reductive stress diabetes” yields only 17,000, a discrepancy of 30 to 1. I believe the underlying issue at the heart of our metabolic woes is reductive stress, which looks to cells like too much cellular energy. In this episode I explain in as simple terms as possible what reductive stress is, why we get it and potential strategies to counteract it.
This episode is really a summary of my recent posts:
ROS as a NAD+ Regenerating, Thermogenic Cycle – The ROS Theory of Obesity Part III, Part 1
NAD+, Reductive Stress and the Magic of Superoxide