I started my sterculia oil (SO) trial with a 16 week n=1 safety trial. I took a lot of the oil – 4400 mg which is 1 tsp daily – for 8 weeks. I would NOT take this much but I wanted to make sure it was safe. Then I didn’t take any for 8 weeks. This was to assess if there was a long half-life.
The next experiment was to test a low dose for effectiveness. I took 600 mg for two weeks. I did not take any other supplements during this time.
I did blood work for lipids, inflammation, thyroid and liver enzymes. The tests were done before taking any oil, after 8 weeks on the high dose, after 8 weeks taking none and then after 2 weeks of taking 600 mg. I also tested my red blood cell membrane fats (phospholipids) monthly to see how they changed.
- From Nov 17th to March 3rd my triglycerides went from 478 (very high) to 134 (normal)
- During the same time my VLDL went from 96 (high) to 24 (normal)
- Both of these dropped after taking the high dose, rebounded after taking none, then dropped to all-time lows after the low dose
- My HDL went from 51 to 65 in the same time, improving my triglyceride:HDL ratio from 9:1 (very bad) to 2:1 (pretty good)
- Free fatty acids were higher but in the normal range while taking SO. This is expected due to increased lipolysis
- I experienced a rise in inflammatory markers after 8 weeks on the high dose. This dropped after stopping the high dose and the drop continued while taking the low dose. Less is probably more with this, I am currently taking 1200 mg (two squeeze bulbs)
- Liver enzymes paralleled the inflammatory numbers. A rise at the high dose but that number continued falling after stopping the high dose even while taking the low dose.
- The rise in inflammatory and liver enzyme numbers were on par with what would be considered “mildly elevated”. Nothing to panic about, but don’t necessarily stay there forever.
- Thyroid numbers moved a bit, I don’t know that much about it.
- Oleic Acid steadily dropped and stearic acid rapidly increased on the high dose. Both trends reversed after cessation and then returned upon starting the low dose.
- The very long chain fats Nervonic Acid MUFA and lignoceric SFA dropped dramatically after taking the high dose, then rebounded after cessation. They continued to rise on the low dose. I expect this is a lagging indicator and they will begin to drop again.
|Brad’s Lipid, Inflammatory, Liver and Thyroid Numbers in Saftey Trial|
|Nov 17 Before||Dec 12 – After 8 wk Hi-Dose||Feb 10 – After 8 Wk None||Mar 3 – 2 Wk Lo-Dose|
|Free Fatty Acids||0.4||0.8||0.6||0.8|
|* Over the normal range; ** – Under the normal range|
|Brad’s OmegaQuant Complete Test Results|
|Dihomo-gamma LA (20:3n6)||1.56||1.35||1.39||1.46||1.34|
Industry Take on Liver Enzymes
To decide whether my rise in liver enzymes was disastrous or not that big a deal, I checked in with “the industry”. According to them, I had a very mild elevation, and this was of course, while consuming not insignificant amounts of ethanol. I feel fine with it.