Brad’s Daily Recipe
- 1200 mg Sterculia Oil (two squeeze bulb squeezes)
- 1500 mg Berberine
- 3000 mg Fish Oil (optional)
I’d like to reach my target weight this year or next, but more importantly I’d like to understand HOW I get there as the journey continues. I’m not interested in losing weight by starving myself, I’d like to FIX my metabolism.
Many (most?) of us are in a torpor-like state as defined by a metabolism largely run on fat (as defined by upregulated PPAR) with a preponderance of PPAR gamma instead of PPAR alpha, and constantly up-regulated SCD1. This metabolic state leads to low metabolic rates, low body temperature, high expression of lipogenic (fat making) genes, and stored body fat.
Torpor and the PPARs
The question is how do we get out of torpor? Based on my preliminary results, I believe that sterculia oil, by inhibiting the enzymatic activity of SCD1, shuts down the runaway regulatory feedback loop of SCD1, PPAR gamma and the other lipogenic genes as demonstrated by the dramatic reduction I saw in my red blood cell phospholipid levels of very long chain fats such as lignoceric acid and nervonic acid. The massive drop in my triglycerides is another piece of supporting evidence. That is a good step!
But it’s not without danger. PPAR alpha seems to be the master regulator of fat burning, but PPAR gamma can increase fat burning as well! I think that PPAR gamma is a crutch. It’s keeping us upright for now and sometimes when you kick the crutch out, it can cause problems. For this reason, in my current trial I am using a PPAR agonist (turns it on) in addition to the sterculia oil.
In the long term, I think that merely increasing the saturation level of our body fat, just like healthy cultures, may lead to huge metabolic improvements. Unfortunately, we don’t yet know how long that will take!
Getting PPAR alpha Back on Board
The key during the transition period – the time when PPAR gamma activity is lowered but before you have gotten rid of enough of your stored PUFA and MUFA – may be to recruit PPAR alpha off of the sidelines. During torpor PPAR gamma goes up and PPAR alpha goes down, but that doesn’t imply that reducing PPAR gamma will increase PPAR alpha! I’m now doing a trial to reduce PPAR gamma while increasing PPAR alpha. The results have been VERY good but I’m only four days in, so I don’t want to present results yet, it still could be a blip but it’s consistent with my reading of the science. Check back soon!
Here is the theory behind the recipe. The sterculia oil is there to continue to shut down the cycle of SCD1-PPAR gamma leading ultimately to a buildup of stearic acid and a loss of oleic acid in my fat tissue. The fish oil is there because my tests have shown that I’m low in long chain omega 3 fats but also to provide membrane fluidity and reduce any potential inflammation from the relatively low dose sterculia oil. Fish oil also happens to stimulate PPAR alpha AND limit expression of SCD1! Nice synergy, huh?
That brings us to the berberine, which is an herbal supplement that has been used in Chinese medicine for thousands of years, is a potent stimulator of PPAR alpha, and has been shown to be very safe in many clinical trials.