The SCD1 Theory Of Obesity

Speed Your Metabolism With Oxidative Stress! Slow It With Antioxidants!

It’s rare to find a scientific paper whose RESULTS are hilarious. Sometimes the authors conclusions are hilarious. If you’ve lived through the last 30 years of articles about the best sources of antioxidants and how to avoid oxidative stress, though, the actual findings of this study​1​ will certainly seem ironic, if not hilarious. I’ve written …

Speed Your Metabolism With Oxidative Stress! Slow It With Antioxidants! Read More »

This is Your Body Temperature on Vegetable Oil

Introduction This article suggests that the reason the Tsimane people of Bolivia experienced a significant, well-documented drop in their body temperature and metabolic rate over the past 15 years is that their fat became less saturated due to newly available “store bought foods”, most of which are loaded with polyunsaturated fat (PUFA).  This drop in …

This is Your Body Temperature on Vegetable Oil Read More »

New List of Additional SCD1 Regulators posted at r/SaturatedFat

There is a great discussion thread for Croissant Diet/ROS Theory of Obesity/SCD1 Theory of Obesity over on reddit. u/Magnum2684 posted a list of additional things that can affect SCD1 levels. It’s a bit confusing to me – when they say “positive” they mean “reduces SCD1 expression” and when they say “negative” they mean “increases SCD1 …

New List of Additional SCD1 Regulators posted at r/SaturatedFat Read More »

Pu’erh Tea is a potent Suppressor of SCD1

Katie sent me this paper.​1​ It actually adds an interesting twist to her story that I already published. She reached out to me last week with her Desaturase Index test results. The test is here. Her score was around a 1.6, which is relatively good and significantly better than where I started out at 2.1. …

Pu’erh Tea is a potent Suppressor of SCD1 Read More »

Dietary Monounsaturated Fat, The SCD1 Theory of Obesity, Part 3

Introduction This is the third part of my SCD1 Theory of Obesity series.  Here are part 1 and part 2.  There is a brief synopsis of the theory below if you don’t want to start from the beginning. Since I published the ROS theory of obesity, one of the most common questions I’ve gotten is, …

Dietary Monounsaturated Fat, The SCD1 Theory of Obesity, Part 3 Read More »

The SCD1 Theory of Obesity Part 2 – The Post Obese Metabolism and What You Can Do About It

AKA The Ros Theory of Obesity Part2, Part 2 Introduction In part 1, I explained that SCD1 is up-regulated in things that are fat and that in fact up-regulating SCD1 in something is sufficient to make it store fat.  Insulin is trying to upregulate SCD1 while leptin down-regulates it.  The mechanism by which leptin down-regulates …

The SCD1 Theory of Obesity Part 2 – The Post Obese Metabolism and What You Can Do About It Read More »

The SCD1 Theory of Obesity, Part 1 – Insulin, Leptin, SCD1 and Thermogenesis

AKA The ROS Theory of Obesity Part 2, Part 1 Introduction In The ROS Theory Of Obesity, I argued that the key determinant of body fatness was the saturation level of fat as it enters the mitochondria.  In The Croissant Diet I addressed the dietary half of this equation, arguing that to lose weight you …

The SCD1 Theory of Obesity, Part 1 – Insulin, Leptin, SCD1 and Thermogenesis Read More »