My last posts were viewed by some as pessimistic in a “once you’re obese, you are stuck” kind of way. I don’t believe that and very soon I will start writing about solutions. Having said that, this post will perhaps seem pessimistic if you thought the previous ones were. I’m working through the basic mechanisms …
I believe that obesity is a fuel partitioning disorder. I’ve argued that when you pack on fat, you essentially “lose” that fuel into your fat tissue. If you don’t have access to fuel, you become hungry and you eat more. In my last article, I started to delve into the mechanism of this. One thing …
Brad discusses The ROS Theory of Obesity, torpid metabolisms, PUFAs in meat and more on The Logos Interviews Podcast with Sebastian Lenk.
In a recent post I talked about three groups of pigs with differing levels of insulin sensitivity. Group 1 was fed a low fat diet and remained insulin sensitive. Group 2 was given 40% of calories as a special soybean oil blend with the triply unsaturated alpha-linolenic acid (ALA) largely removed. These pigs became what …
PPAR gamma With Oxidized PUFA is the Gatekeeper to Metabolic Inflexibility Read More »
Brad talking about the latest Fire In A Bottle concepts with Brian Sanders. We pack in a lot of info in under 2 hours!
Mr Bill’s podcast is not a health-based, typically. This is a great starting point if you you’re looking for a podcast about Fire In A Bottle concepts with little technical background.
This 2 part podcast is comprehensive look at the topics discussed on Fire In A Bottle to date. Part One. Part Two.
This is wide-ranging discussion about the ideas discussed on Fire In A Bottle, including torpor, SCD1 and Sterculia Oil.
This is from the EPIC Potsdam study in Germany, which looked at the association between membrane phospholipid composition, diet and type 2 diabetes risk.​1​ Read it and weep. It looks like linoleic acid prevents diabetes after all. Time to shut down the blog, run out and buy some corn oil. KIDDING! Remember what happened to …
Hap MD asked me if I had any thoughts on Ossabaw pigs. They are interesting because they are one of the only animals other than humans who spontaneously have heart attacks (the only?). Ossabaw piings are descended from Spanish pigs that were dropped on Ossabaw island off of the coast of Georgia, United States, in …
I’ve written a lot about the strong correlation between the Desaturase Index (DI) and human obesity. DI is an indirect indicator of the activity of the SCD1 gene. I have also suggested that the consumption of linoleic acid – the primary Omega 6 polyunsaturated fat (PUFA) in the human diet found in vegetable oil, bacon …
This Is How Linoleic Acid Makes You Fat, Leptin Resistant and Torpid Read More »
I mentioned somewhere that I was leptin resistant somewhere and in the comments of the blog someone asked how I knew that I was. My immediate response was, “because I’m fat.” But also, “because I have a high desaturase index (DI), indicating high activity of the enzyme SCD1.” A high DI is an indicator that …
There are many believers in a reductionist calories in, calories out (CICO) view of the world. People in this tribe often say things like, “to lose weight, you just have to eat less and move more.” I want to be clear, I believe in calories in, calories out from a strict thermodynamic perspective. Calories you …
Introduction This is part of my Torpor, Sloth and Gluttony series where I will argue that obesity is caused not by sloth and gluttony but by specific metabolic processes. Leptin is a hormone produced by fat cells. The fatter one gets, the more circulating leptin one has. Leptin is the master hormone whose job is …
In the comments of SCD1 CAUSES Humans to Store Fat, David N posted a link to a paper​​1​ that I referenced in The SCD1 Theory of Obesity Part Two where liver fat accumulation and insulin resistance in rats fed a high fructose diet were prevented by supplementing with sterculia oil. I hadn’t looked at the …
