The human body has multiple ways of eliminating the hydrogen peroxide that is generated during metabolism. Glutathione and Thioredoxin rely on a steady stream of NADPH to eliminate the peroxide. This causes the NAD+/NADH pool to become more oxidized due to NADPH being regenerated from NADH by the mitochondrial enzyme NNT. In short, peroxide removal …
People talk about calories-in, calories-out. It is the idea that weight will be gained if you eat extra calories or lost if you burn extra calories, say by exercising. Many studies have been done and calorie restriction or exercise for weight loss and the results are very: these are losing strategies. In this video I …
I was responding to an email from someone who grazes hogs in a oak forest. They wondered about the effect this would have on the linoleic acid content of their pork. As I was responding, I thought that this was an email a lot of people might like to read, so I am posting a …
This video is a supplement to the post Reductive Stress Causes Oxidative Stress (Take 2). You can find the citations there.
With every new paper that comes out it becomes clearer that reductive stress is the root cause of oxidative stress. I tried to explain this before, but I’m not sure how well I did. Here’s how it works: Some Initiating Event There is an initiating event which pushes the cell into reductive stress, as defined …
Reductive Stress Causes Oxidative Stress (Take 2) Read More »
Unless you’ve been living under a rock, you’ve probably noticed that there is controversy surrounding the value of livestock agriculture and its end-products: milk, eggs and meat. Detractors argue that livestock agriculture is inefficient – livestock eat grain that could be fed to humans. The condition that the animals live in is inhumane, there is …
At the end of my series on how seed oils cause reductive stress, I said I would be back soon with ideas for what to do about it. This is the first article and I’m going to look at two cheap supplements that have been around a long time and look at how they work …
Battling Reductive Stress: Pyruvate and L-Carnitine Read More »
This post comes out a recent conversation I had with Tucker Goodrich and David Gornoski (not live yet, I’ll post it when its out). Tucker was arguing that obesity was caused by endogenous cannabinoids that are made from linoleic acid. I was arguing that obesity is caused by reductive stress. As I pointed out on …
Reductive Stress Gives You The Munchies by Activating D6D Read More »
Is it lazy to just post my own tweet and call it an article? You decide. Reducive stress(RS) vs Oxidative stress (OS): they are not opposites, RS is the POTENTIAL for OS. Reduced things (NADH, NADPH, GSH) are electron donors. If they give those electrons to O2 it makes superoxide (O2-). You can't make O2- …
Reductive stress is the POTENTIAL for oxidative stress Read More »
Georgi is a follower of Ray Peat’s ideas and is extending them based on the latest science. I think this is a very interesting discussion. Don’t take my word for it. Still listening & enjoying with 30 min to go (need to break for something, reluctantly). From about 40mins in the discussion builds to excellence, …
Since I published The Croissant Diet there has been much interest in the scientific article I call “The banana milkshake study“​1​. The study showed that ingestion of 24g of stearic acid in a banana shake after a two day low fat diet caused mitochondrial fusion and a drop in circulating acylcarnitines. We are very interested …
How Stearic Acid Battles Reductive Stress; The Banana Milkshake Study Redux Read More »
Obesogens are environmental toxins that make you fat. A commonality among them is that they activate receptors such as hormone receptors, androgen receptors, and perhaps most importantly, receptors in the nuclear receptor superfamily. Of course, if certain chemicals can make you fat, you have to really question the calories-in-calories-out theory of obesity. Certain chemicals can …
PUFA as an obesogen; How Seed Oils Cause Reductive Stress, Part VI Read More »
Kevin and I had a great convo about all things FIAB. This is a great preview of topics on this blog.
In this series, I have argued that consuming seed oils causes reductive stress in the mitochondria as defined by high levels of acetyl-CoA and NADH. You could also call this “too much fuel” in the mitochondira, AKA a flooded engine. If I am correct, it should be easy to demonstrate in the short term that …
In this series I’ve been using the analogy of a flooded engine to help to understand some pretty complicated dynamics that happen in the mitochondria when we burn fat. The details can be overwhelming but the high-level perspective is pretty straightforward. If you fill the mitochondria with too much fuel and not enough oxygen, the …
