Long Chain Saturated Fat Causes Fat Loss in Mice

If you’ve been reading along you know that by this point we’ve shown that long chain saturated fat consumption causes ROS production in the mitochondria which causes short term physiological insulin resistance. The ROS theory of obesity suggests that physiological insulin resistance should prevent fat storage in peripheral fat cells (adipocytes). I’ve been dancing around …

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The Amount of Polyunsaturated fat in the Modern American Diet Fattens up Mice Without Additional Calories

In this series we’ve discussed the fact that saturated fat oxidation leads to ROS production in the mitochondria which makes peripheral fat cells “physiologically insulin resistant” which prevents them from switching from fat burning to fat storage. We’ve shown that saturated fat reversibly induces insulin resistance in people in the short term and that a …

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Unsaturated Fat Prevents Physiological Insulin Resistance In Humans

This paper studied the effect of a ketogenic diet composed largely of saturated fat compared to one composed largely of unsaturated fat. Ketogenic diets are high in fat and low in carbohydrate and protein. Ketogenic diets are known to stimulate physiological insulin resistance that goes away after a few days of eating a carbohydrate rich …

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Saturated Fat Causes Physiological Insulin Resistance in Humans

In previous posts I have laid out the argument that metabolism of long chain saturated fat creates mitochondrial ROS which causes short term insulin resistance while the saturated fat is oxidized. Insulin tells the bodies cells to switch from fat metabolism to glucose metabolism and causes fat cells to absorb glucose, convert it to fat …

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Two Elegant Experiments Demonstrating that ROS is The Signal

If you’been reading through the Introduction to Fire in a Bottle series, I explained the concept of oxidation, discussed the oxygen catastrophe and its implications for evolution, I introduced our unlikely hero superoxide and then we met our bodies inbuilt antioxidant defense system. Along the way I introduced the key point that Reactive Oxygen Species …

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The Great Oxygenation

The primordial atmosphere of the earth didn’t contain Oxygen (O2). The atmosphere was a “reducing atmosphere”, the exact opposite of today’s “oxidizing atmosphere”. Somewhere along the line life evolved. Single-celled organisms. Weirdos by today’s standards. Methanogens and sulfate-reducing microorganisms. That was just life for a couple billion years. And then chlorophyll evolved. Chlorophyll changes everything. …

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