New Video: Reductive Stress Causes Oxidative Stress
This video is a supplement to the post Reductive Stress Causes Oxidative Stress (Take 2). You can find the citations there.
Reductive Stress Causes Oxidative Stress (Take 2)
With every new paper that comes out it becomes clearer that reductive stress is the root cause of oxidative stress. I tried to explain this before, but I’m not sure how well I did. Here’s how it works: Some Initiating Event There is an initiating event which pushes the cell into reductive stress, as defined …
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Sustainable Pork and Metabolic Health in China, featuring Coprophagy: Livestock Agriculture, Part 1
Unless you’ve been living under a rock, you’ve probably noticed that there is controversy surrounding the value of livestock agriculture and its end-products: milk, eggs and meat. Detractors argue that livestock agriculture is inefficient – livestock eat grain that could be fed to humans. The condition that the animals live in is inhumane, there is …
Battling Reductive Stress: Pyruvate and L-Carnitine
At the end of my series on how seed oils cause reductive stress, I said I would be back soon with ideas for what to do about it. This is the first article and I’m going to look at two cheap supplements that have been around a long time and look at how they work …
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Reductive Stress Gives You The Munchies by Activating D6D
This post comes out a recent conversation I had with Tucker Goodrich and David Gornoski (not live yet, I’ll post it when its out). Tucker was arguing that obesity was caused by endogenous cannabinoids that are made from linoleic acid. I was arguing that obesity is caused by reductive stress. As I pointed out on …
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Reductive stress is the POTENTIAL for oxidative stress
Is it lazy to just post my own tweet and call it an article? You decide. Reducive stress(RS) vs Oxidative stress (OS): they are not opposites, RS is the POTENTIAL for OS. Reduced things (NADH, NADPH, GSH) are electron donors. If they give those electrons to O2 it makes superoxide (O2-). You can't make O2- …
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Brad chats with Georgi Dinkov
Georgi is a follower of Ray Peat’s ideas and is extending them based on the latest science. I think this is a very interesting discussion. Don’t take my word for it. Still listening & enjoying with 30 min to go (need to break for something, reluctantly). From about 40mins in the discussion builds to excellence, …
How Stearic Acid Battles Reductive Stress; The Banana Milkshake Study Redux
Since I published The Croissant Diet there has been much interest in the scientific article I call “The banana milkshake study“​1​. The study showed that ingestion of 24g of stearic acid in a banana shake after a two day low fat diet caused mitochondrial fusion and a drop in circulating acylcarnitines. We are very interested …
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PUFA as an obesogen; How Seed Oils Cause Reductive Stress, Part VI
Obesogens are environmental toxins that make you fat. A commonality among them is that they activate receptors such as hormone receptors, androgen receptors, and perhaps most importantly, receptors in the nuclear receptor superfamily. Of course, if certain chemicals can make you fat, you have to really question the calories-in-calories-out theory of obesity. Certain chemicals can …
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Brad Talks ROS Theory of Obesity, Torpor and Reductive Stress with Kevin Stock
Kevin and I had a great convo about all things FIAB. This is a great preview of topics on this blog.
Seed oils make lean people behave like fat people, metabolically speaking; How seed oils cause reductive stress, part V
In this series, I have argued that consuming seed oils causes reductive stress in the mitochondria as defined by high levels of acetyl-CoA and NADH. You could also call this “too much fuel” in the mitochondira, AKA a flooded engine. If I am correct, it should be easy to demonstrate in the short term that …
Carbon Recycling: What Happens to Seed Oils When You Eat Them? ; How Seed Oils Cause Reductive Stress, Part IV
In this series I’ve been using the analogy of a flooded engine to help to understand some pretty complicated dynamics that happen in the mitochondria when we burn fat. The details can be overwhelming but the high-level perspective is pretty straightforward. If you fill the mitochondria with too much fuel and not enough oxygen, the …
Dietary Linoleic Acid Does Not Reduce Diabetes Risk
Introduction In a recent Twitter thread, Simon Hill, MSc. BSc. tweeted this about a recent podcast episode of The Proof featuring Bill Harris, PhD. Did you listen to the debate on my show? Omega 6 being a driver of CHD is a very hard position to take. — Simon Hill MSc, BSc (Hons) (@theproof) June …
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Acetylation Turns on Lipogenic Enzymes; How Seed Oils Cause Reductive Stress, Part III
I argued in part II of this series that consumption of unsaturated fats fails to create a properly oxygenated fuel mix, which leads to a rise in mitochondrial acetyl-CoA and NADH levels along with a drop in NAD+ levels. This is reductive stress. The system that replenishes NAD+ while burning fat is the production and …
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The Mitochondrial Bottleneck as the carburetor screw; How seed oils cause reductive stress, part II
In part I of this series I introduced the analogy of reductive stress as a flooded engine. If there is too much fuel and not enough air, an engine will flood. Elevated circulating acylcarnitines in obesity are analogous to black smoke out of the tailpipe of a flooded engine – unburnt fuel spewing back out …