Brad Marshall

Are You In Deep Torpor? SCD1 Theory Of Obesity Summary So Far And Hamsters!

Introduction It’s time for the season finale! Next week I will pivot to discussing my personal results of using sterculia oil to inhibit SCD1. In this post I will summarize my posts on the topic to date before bringing the thread to a near term conclusion using an example that in retrospect will be so …

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Very Long Chain Saturated and Monounsaturated Fats

Overview Very Long Chain Fatty Acids (VLCFA) I’ve become very interested in very long chain fats – those weird ones that you ignored on your OmegaQuant test. Things like behenic acid, a 22 carbon length saturated fat. In Good PPAR, Bad PPAR, I pointed out that there is a positive feedback loop where too much …

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Membrane Phospholipid Composition of Different Populations

I’ve been promoting the OmagaQuant complete test as a way to calculate your Desaturase Indix (DI or DI18) to know your SCD1 levels. This is calculated by dividing your oleic acid (18:1) by your stearic acid (18:0). There are a lot of questions about what people’s numbers SHOULD look like. Ideally your DI should be …

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Good PPAR, Bad PPAR

Overview Introduction I introduced PPAR alpha in Dietary Monounsaturated Fat as an altogether good actor, doing things like increasing the rate of fat burning.  The PPAR genes are indeed master metabolic regulators.  In this post I’m going to introduce PPAR alpha’s troubled sibling, PPAR gamma.   The PPARs are transcription factors, which is to say that …

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Fat Newborns; Sloth and Gluttony Part 1

Introduction The most common explanation given for the recent wave of obesity is that “We don’t work as hard as we used to and we overeat.”  This is what evolutionary biologist Stephen Jay Gould calls a “just-so story”, an untestable narrative explanation for a cultural practice, a biological trait, or behavior of humans or other …

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David’s Story

This is a pretty great testimonial to the potential of The Croissant Diet. David really took this principle seriously, eating croissants with butter and cheese, cheseburgers and Haagen-Das. He did a great job of collecting data during his journey, including before and after photos. Some days he consumed close to 5000 calories! Detailed reports of …

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Really Good Historical Video About The History of SCD1 research Posted at r/SaturatedFat

This was posted by a user of the reddit group r/SaturatedFat. This is a great forum for discussing issues relevant to Fire In A Bottle, Hyperlipid, SCD1, etc. This post is particularly interesting – Dr. Ntambi did much of the early research on SCD1. You can hear his thoughts and findings about it at the …

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Bear Hunting Season; Native Americans Hunted Bear When The PUFA Content Was Lowest

Introduction This is a followup to my post Native Americans Removed Acorn Oil and Replaced It With Bear Fat. It also carries on the theme of adaptive thermogensis, which I introduced in This is Your Body Temperature on Vegetable Oil and continued in The Body Fat Saturation Of Starch Eaters; Linoleic Acid Dysregulates SCD1. In …

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Lori’s Story

Lori reached out to me wanting to share her story. She initially sent me this email: First of all, thank you!I’ve been doing TCD since your first post.I’m a 63 year old female who is kind of dietary lazy.I didn’t count macros or calories or anything else. For about a year, I had one rule.No …

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The Body Fat Saturation Of Starch Eaters; Linoleic Acid Dysregulates SCD1

I’ve argued in The SCD1 Theory of Obesity Part One and Part Two, as well as in This Is Your Body Temperature On Vegetable Oil that if your body fat is highly saturated, you will respond to an increase in body fat by increasing your metabolic rate through a process known as adaptive thermogenesis. In …

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Native Americans Removed Acorn Oil and Replaced It With Bear Fat

Introduction In a previous article, I argued that a recent drop in the body temperatures of the Tsimane people of Bolivia was caused by the introduction of vegetable oil to a mostly starch diet. Native Americans used acorns as a staple starch, but they removed the oil form them before eating. However, they often added …

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Speed Your Metabolism With Oxidative Stress! Slow It With Antioxidants!

It’s rare to find a scientific paper whose RESULTS are hilarious. Sometimes the authors conclusions are hilarious. If you’ve lived through the last 30 years of articles about the best sources of antioxidants and how to avoid oxidative stress, though, the actual findings of this study​1​ will certainly seem ironic, if not hilarious. I’ve written …

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This is Your Body Temperature on Vegetable Oil

Introduction This article suggests that the reason the Tsimane people of Bolivia experienced a significant, well-documented drop in their body temperature and metabolic rate over the past 15 years is that their fat became less saturated due to newly available “store bought foods”, most of which are loaded with polyunsaturated fat (PUFA).  This drop in …

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New List of Additional SCD1 Regulators posted at r/SaturatedFat

There is a great discussion thread for Croissant Diet/ROS Theory of Obesity/SCD1 Theory of Obesity over on reddit. u/Magnum2684 posted a list of additional things that can affect SCD1 levels. It’s a bit confusing to me – when they say “positive” they mean “reduces SCD1 expression” and when they say “negative” they mean “increases SCD1 …

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