So like I was saying, biology is weird. AMPK and SCD1 are a literal teeter totter. When SCD1 goes up, AMPK goes down. When AMPK goes up, SCD1 goes down. This matters because, as I pointed out in the last post, AMPK can help to keep us out of torpor. In hibernating animals and obese …
In the comments of SCD1 CAUSES Humans to Store Fat, David N posted a link to a paper​​1​ that I referenced in The SCD1 Theory of Obesity Part Two where liver fat accumulation and insulin resistance in rats fed a high fructose diet were prevented by supplementing with sterculia oil. I hadn’t looked at the …
The title of “High resting metabolic rate among Amazonian forager-horticulturalists experiencing high pathogen burden” makes it unambiguous as to the authors feelings about why the Tsimane have high metabolic rates. They include this graph to show just how unique the Tsimane are. I recently wrote about the plunge in American Metabolic rates in women between …
As a biologist, I always think in evolutionary terms. All mammals share a single ancestor who had developed a warm-blooded metabolism. Many mammals hibernate: bears, ground squirrels, skunks, bats, anteaters, etc. To hibernate, you have to throttle back your warm-blooded metabolism to a torpid one allowing your metabolic rate and body temperature to drop. Since …
Recently I posted an article recommending combining sterculia oil with berberine and/or fish oil as a way to escape torpor. I chose this combination because they mimic the effects of leptin, the hormone produced by our fat cells whose job is to keep us lean but to which most of us are resistant. As discussed …
n=1 on Escaping Torpor: Turning off PPAR gamma and turning on Fat Burning Read More »
Brad’s Daily Recipe Introduction I’d like to reach my target weight this year or next, but more importantly I’d like to understand HOW I get there as the journey continues. I’m not interested in losing weight by starving myself, I’d like to FIX my metabolism. Many (most?) of us are in a torpor-like state as …
Inroduction So I have a fancy metabolic tester to track my metabolic rate. It’s honestly pretty amazing if you have $7500 burning a hole on your pocket. Sometimes they have deals and I’m an affiliate so if you give them my code “BMarsh”, you’ll get $600 off. If you can’t afford a metabolic tester, here’s …
Study Design I started my sterculia oil (SO) trial with a 16 week n=1 safety trial. I took a lot of the oil – 4400 mg which is 1 tsp daily – for 8 weeks. I would NOT take this much but I wanted to make sure it was safe. Then I didn’t take any …
Introduction It’s time for the season finale! Next week I will pivot to discussing my personal results of using sterculia oil to inhibit SCD1. In this post I will summarize my posts on the topic to date before bringing the thread to a near term conclusion using an example that in retrospect will be so …
Are You In Deep Torpor? SCD1 Theory Of Obesity Summary So Far And Hamsters! Read More »
Overview Very Long Chain Fatty Acids (VLCFA) I’ve become very interested in very long chain fats – those weird ones that you ignored on your OmegaQuant test. Things like behenic acid, a 22 carbon length saturated fat. In Good PPAR, Bad PPAR, I pointed out that there is a positive feedback loop where too much …
Very Long Chain Saturated and Monounsaturated Fats Read More »
I’ve been promoting the OmagaQuant complete test as a way to calculate your Desaturase Indix (DI or DI18) to know your SCD1 levels. This is calculated by dividing your oleic acid (18:1) by your stearic acid (18:0). There are a lot of questions about what people’s numbers SHOULD look like. Ideally your DI should be …
Membrane Phospholipid Composition of Different Populations Read More »
Overview Introduction I introduced PPAR alpha in Dietary Monounsaturated Fat as an altogether good actor, doing things like increasing the rate of fat burning. The PPAR genes are indeed master metabolic regulators. In this post I’m going to introduce PPAR alpha’s troubled sibling, PPAR gamma. The PPARs are transcription factors, which is to say that …
Introduction The most common explanation given for the recent wave of obesity is that “We don’t work as hard as we used to and we overeat.” This is what evolutionary biologist Stephen Jay Gould calls a “just-so story”, an untestable narrative explanation for a cultural practice, a biological trait, or behavior of humans or other …
Introduction This is a followup to my post Native Americans Removed Acorn Oil and Replaced It With Bear Fat. It also carries on the theme of adaptive thermogensis, which I introduced in This is Your Body Temperature on Vegetable Oil and continued in The Body Fat Saturation Of Starch Eaters; Linoleic Acid Dysregulates SCD1. In …
Bear Hunting Season; Native Americans Hunted Bear When The PUFA Content Was Lowest Read More »
I’ve argued in The SCD1 Theory of Obesity Part One and Part Two, as well as in This Is Your Body Temperature On Vegetable Oil that if your body fat is highly saturated, you will respond to an increase in body fat by increasing your metabolic rate through a process known as adaptive thermogenesis. In …
The Body Fat Saturation Of Starch Eaters; Linoleic Acid Dysregulates SCD1 Read More »
